DRD4 Antikörper (AA 365-391)

Produktnummer ABIN1882235

Der Maus Monoklonal Anti-DRD4-Antikörper wurde für WB validiert. Er ist geeignet, DRD4 in Proben von Human und Maus zu detektieren. Es sind 4+ Publikationen verfügbar.

Kurzübersicht für DRD4 Antikörper (AA 365-391) (ABIN1882235)

Target: DRD4 (Dopamine Receptor D4 (DRD4))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DRD4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 625CT1-5-4

Produktdetails anti-DRD4 Antikörper

Bindungsspezifität: AA 365-391

Aufreinigung: This antibody is purified through a protein G column, followed by dialysis against PBS.

Immunogen: This DRD4 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 365-391 amino acids from the Central region of human DRD4.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1:100~250

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified monoclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-DRD4 Antikörper (ABIN1882235)

Zeng, Ye, Lu, Chua, Tan, Zhong: "Chiral Brønsted acid catalyzed enantioselective addition of alpha-isocyanoacetamides to aldehydes." in: Organic letters, Vol. 12, Issue 10, pp. 2414-7, (2010) (PubMed).

Lai, Zhu, Huo, Sun, Yu, Wang, Chai, Li: "Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction." in: Brain research, Vol. 1359, pp. 227-32, (2010) (PubMed).

Gadow, Devincent, Olvet, Pisarevskaya, Hatchwell: "Association of DRD4 polymorphism with severity of oppositional defiant disorder, separation anxiety disorder and repetitive behaviors in children with autism spectrum disorder." in: The European journal of neuroscience, Vol. 32, Issue 6, pp. 1058-65, (2010) (PubMed).

Chio, Drong, Riley, Gill, Slightom, Huff: "D4 dopamine receptor-mediated signaling events determined in transfected Chinese hamster ovary cells." in: The Journal of biological chemistry, Vol. 269, Issue 16, pp. 11813-9, (1994) (PubMed).

Details zu DRD4

Target: DRD4 (Dopamine Receptor D4 (DRD4))

Andere Bezeichnung: DRD4

Hintergrund: This gene encodes the D4 subtype of the dopamine receptor. The D4 subtype is a G-protein coupled receptor which inhibits adenylyl cyclase. It is a target for drugs which treat schizophrenia and Parkinson disease. Mutations in this gene have been associated with various behavioral phenotypes, including autonomic nervous system dysfunction, attention deficit/hyperactivity disorder, and the personality trait of novelty seeking. This gene contains a polymorphic number (2-10 copies) of tandem 48 nt repeats, the sequence shown contains four repeats.

Molekulargewicht: 43901

NCBI Accession: NP_000788

UniProt: P21917

Pathways: cAMP Metabolic Process, Synaptic Membrane, Proton Transport, Photoperiodism, Negative Regulation of Transporter Activity