TK2 Antikörper (N-Term)

Produktnummer ABIN1882141

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch TK2 in WB. Es zeigt Reaktivität gegenüber Proben von Human und Maus.

Kurzübersicht für TK2 Antikörper (N-Term) (ABIN1882141)

Target: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TK2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB5434

Produktdetails anti-TK2 Antikörper

Bindungsspezifität: AA 8-38, N-Term

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Immunogen: This Thymidine Kinase 2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 8-38 amino acids from the N-terminal region of human Thymidine Kinase 2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Details zu TK2

Target: TK2 (Thymidine Kinase 2, Mitochondrial (TK2))

Hintergrund: Thymidine kinase-2 (TK2) is a deoxyribonucleoside kinase that phosphorylates thymidine, deoxycytidine, and deoxyuridine, and also phosphorylates antiviral and anticancer nucleoside analogs. Both recombinant and native forms of the enzyme have broad substrate specificity and complex kinetics, suggesting that it may play a role in the activation of chemotherapeutic nucleoside analogs. The highest levels of expression are observed in testis and ovary. The main supply of deoxyribonucleotides (dNTPs) for mitochondrial DNA synthesis comes from the salvage pathway initiated by deoxyguanosine kinase (DGK) and TK2. The association of mitochondrial DNA depletion with mutations in the genes encoding these 2 kinases suggests that the salvage pathway enzymes are involved in the maintenance of balanced mitochondrial dNTP pools.

Molekulargewicht: 31005

NCBI Accession: NP_001166114, NP_001166115, NP_001258864, NP_004605

UniProt: O00142

Pathways: Mitotic G1-G1/S Phases