YBX1 Antikörper (AA 149-178)

Produktnummer ABIN1882002

Dieses Anti-YBX1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von YBX1 in WB und IF. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für YBX1 Antikörper (AA 149-178) (ABIN1882002)

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser YBX1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF)

Klon: RB41913

Produktdetails anti-YBX1 Antikörper

Bindungsspezifität: AA 149-178

Homologie: B, M, Rb, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This YBX1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 149-178 amino acids from the Central region of human YBX1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-YBX1 Antikörper (ABIN1882002)

Osada, Uno, Mineta, Kameoka, Takahashi, Terao: "Ancient genome-wide admixture extends beyond the current hybrid zone between Macaca fascicularis and M. mulatta." in: Molecular ecology, Vol. 19, Issue 14, pp. 2884-95, (2010) (PubMed).

Yu, Yip, Tan, Thike, Matsumoto, Tsujimoto, Bay: "Y-box binding protein 1 is up-regulated in proliferative breast cancer and its inhibition deregulates the cell cycle." in: International journal of oncology, Vol. 37, Issue 2, pp. 483-92, (2010) (PubMed).

Lovett, Cheng, Cape, Pollock, Mertens: "YB-1 alters MT1-MMP trafficking and stimulates MCF-7 breast tumor invasion and metastasis." in: Biochemical and biophysical research communications, Vol. 398, Issue 3, pp. 482-8, (2010) (PubMed).

Takahashi, Shimajiri, Izumi, Hirano, Kashiwagi, Yasuniwa, Wu, Han, Akiyama, Nishizawa, Sasaguri, Kohno: "Y-box binding protein-1 is a novel molecular target for tumor vessels." in: Cancer science, Vol. 101, Issue 6, pp. 1367-73, (2010) (PubMed).

To, Fotovati, Reipas, Law, Hu, Wang, Astanehe, Davies, Lee, Stratford, Raouf, Johnson, Berquin, Royer, Eaves, Dunn: "Y-box binding protein-1 induces the expression of CD44 and CD49f leading to enhanced self-renewal, mammosphere growth, and drug resistance." in: Cancer research, Vol. 70, Issue 7, pp. 2840-51, (2010) (PubMed).

Details zu YBX1

Target: YBX1 (Y Box Binding Protein 1 (YBX1))

Andere Bezeichnung: YBX1

Hintergrund: Mediates pre-mRNA alternative splicing regulation. Binds to splice sites in pre-mRNA and regulates splice site selection. Binds and stabilizes cytoplasmic mRNA. Contributes to the regulation of translation by modulating the interaction between the mRNA and eukaryotic initiation factors (By similarity). Binds to promoters that contain a Y-box (5'-CTGATTGGCCAA-3'), such as HLA class II genes. Regulates the transcription of numerous genes. Promotes separation of DNA strands that contain mismatches or are modified by cisplatin. Has endonucleolytic activity and can introduce nicks or breaks into double-stranded DNA (in vitro). May play a role in DNA repair. Component of the CRD-mediated complex that promotes MYC mRNA stability.

Molekulargewicht: 35924

NCBI Accession: NP_004550

UniProt: P67809

Pathways: Regulation of Muscle Cell Differentiation