TXNIP Antikörper (AA 116-145)

Produktnummer ABIN1881961

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TXNIP in WB und IHC (p). Er zeigt eine Reaktivität gegenüber Maus und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für TXNIP Antikörper (AA 116-145) (ABIN1881961)

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TXNIP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB30652

Produktdetails anti-TXNIP Antikörper

Bindungsspezifität: AA 116-145

Homologie: Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This Mouse Txnip antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 116-145 amino acids from the Central region of mouse Txnip.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:2000. IHC-P: 1:100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-TXNIP Antikörper (ABIN1881961)

Martin: "[Growing old]." in: Revue médicale suisse, Vol. 6, Issue 256, pp. 1424, (2010) (PubMed).

Kwon, Lim, Han, Lee, Yoon, Nam, Choi, Kim, Won, Kim: "The role of vitamin D3 upregulated protein 1 in thioacetamide-induced mouse hepatotoxicity." in: Toxicology and applied pharmacology, Vol. 248, Issue 3, pp. 277-84, (2010) (PubMed).

Kwon, Won, Suh, Jeon, Shao, Yoon, Chung, Kim, Kim, Nam, Yoon, Kim, Kim, Kim, Kim, Kim, Choi: "Vitamin D3 upregulated protein 1 suppresses TNF-?-induced NF-?B activation in hepatocarcinogenesis." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 185, Issue 7, pp. 3980-9, (2010) (PubMed).

Ren, Shi, Wang, Li, Wu, Li, Zhang, Duan: "p38 MAPK pathway is involved in high glucose-induced thioredoxin interacting protein induction in mouse mesangial cells." in: FEBS letters, Vol. 584, Issue 15, pp. 3480-5, (2010) (PubMed).

Shao, Kim, Shin, Kim, Suh, Piao, Jeong, Lee, Yoon, Lim, Kim, Ahn, Choi: "TXNIP regulates germinal center generation by suppressing BCL-6 expression." in: Immunology letters, Vol. 129, Issue 2, pp. 78-84, (2010) (PubMed).

Details zu TXNIP

Target: TXNIP (Thioredoxin Interacting Protein (TXNIP))

Andere Bezeichnung: Txnip

Hintergrund: May act as an oxidative stress mediator by inhibiting thioredoxin activity or by limiting its bioavailability. Interacts with COPS5 and restores COPS5-induced suppression of CDKN1B stability, blocking the COPS5-mediated translocation of CDKN1B from the nucleus to the cytoplasm. Functions as a transcriptional repressor, possibly by acting as a bridge molecule between transcription factors and corepressor complexes, and over-expression will induce G0/G1 cell cycle arrest. Required for the maturation of natural killer cells.

Molekulargewicht: 44363

NCBI Accession: NP_001009935, NP_076208

UniProt: Q8BG60

Pathways: Protein targeting to Nucleus, Platelet-derived growth Factor Receptor Signaling, Inflammasome