TSC1 Antikörper (Tuberous Sclerosis 1) (pTyr297)

Details for Product anti-TSC1 Antibody No. ABIN1881932, Anbieter: Anmelden zum Anzeigen
Antigen
  • LAM
  • TSC
  • hamartin
  • mKIAA0243
  • tsc1
  • wu:fc38b04
  • TSC complex subunit 1
  • tuberous sclerosis 1
  • TSC complex subunit 1b
  • TSC1
  • Tsc1
  • tsc1b
  • tsc1
Epitop
pTyr297
50
42
38
38
38
37
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
19
16
12
12
10
9
7
7
7
7
4
4
4
3
3
3
3
3
2
2
2
1
1
1
1
1
1
1
1
Reaktivität
Human
446
364
168
28
7
6
5
1
1
Wirt
Kaninchen
710
55
19
2
Klonalität (Klon)
Polyklonal ()
Konjugat
Dieser TSC1 Antikörper ist unkonjugiert
67
67
67
64
64
64
5
5
5
5
5
3
3
3
3
3
3
2
2
Applikation
Dot Blot (DB)
519
503
163
68
39
34
30
21
17
9
4
2
2
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This TSC1 Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y297 of human TSC1.
Klon RB42251
Reinigung This antibody is purified through a protein A column, followed by peptide affinity purification. Peptide Affinity Purified Rabbit Polyclonal Antibody (Pab)
Andere Bezeichnung TSC1 (TSC1 Antibody Abstract)
Hintergrund This gene encodes a growth inhibitory protein thought to play a role in the stabilization of tuberin. Mutations in this gene have been associated with tuberous sclerosis. Alternative splicing results in multiple transcript variants.

Synonyms: TSC1, KIAA0243, TSC, Hamartin, Tuberous sclerosis 1 protein
NCBI Accession NP_001155899, NP_001155898, NP_000359
UniProt Q92574
Pathways RTK Signalweg, AMPK Signaling, Regulation of Cell Size, Tube Formation
Applikations-hinweise DB: 1:500
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.5 mg/mL
Buffer Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Bilder des Herstellers
Dot Blot (DB) image for anti-Tuberous Sclerosis 1 (TSC1) (pTyr297) antibody (ABIN1881932) Dot blot analysis of TSC1 Antibody (Phospho Y297) Phospho-specific Pab (ABIN1881932) ...
Produkt verwendet in: Mehta, Vazquez, Kulkarni, Kerrigan, Atwal, Metsugi, Toppmeyer, Levine, Hirshfield: "Polymorphic variants in TSC1 and TSC2 and their association with breast cancer phenotypes." in: Breast cancer research and treatment, Vol. 125, Issue 3, pp. 861-8, 2011 (PubMed).

Hoogeveen-Westerveld, Exalto, Maat-Kievit, van den Ouweland, Halley, Nellist: "Analysis of TSC1 truncations defines regions involved in TSC1 stability, aggregation and interaction." in: Biochimica et biophysica acta, Vol. 1802, Issue 9, pp. 774-81, 2010 (PubMed).

Mieulet, Lamb: "Tuberous sclerosis complex: linking cancer to metabolism." in: Trends in molecular medicine, Vol. 16, Issue 7, pp. 329-35, 2010 (PubMed).

Guo, Ying, Zhang, Yuan, Qian, Wang, Yang, He: "Tandem affinity purification and identification of the human TSC1 protein complex." in: Acta biochimica et biophysica Sinica, Vol. 42, Issue 4, pp. 266-73, 2010 (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, 2010 (PubMed).

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