Der Kaninchen Polyklonal anti-TSC1 Antikörper (Klon RB42204) (ABIN1881924) detektiert spezifisch TSC1 in WB.
Dieser Antikörper reagiert spezifisch mit Proben aus Human.
This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 395-424 amino acids from the Central region of human TSC1.
TSC1
Reaktivität: Maus
DB
Wirt: Kaninchen
Polyclonal
RB41240
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Target
TSC1
(Tuberous Sclerosis 1 (TSC1))
Andere Bezeichnung
TSC1
Hintergrund
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling. Seems not to be required for TSC2 GAP activity towards RHEB. Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling.