This antibody is purified through a protein A column, followed by peptide affinity purification.
Immunogen
This Mouse TSC1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 1117-1144 amino acids from the C-terminal region of mouse TSC1.
TSC1
Reaktivität: Human, Maus, Schaf
ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro)
Wirt: Kaninchen
Polyclonal
unconjugated
Applikationshinweise
WB: 1:1000
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Buffer
Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
4 °C,-20 °C
Haltbarkeit
6 months
Target
TSC1
(Tuberous Sclerosis 1 (TSC1))
Andere Bezeichnung
TSC1
Hintergrund
In complex with TSC2, inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (By similarity). Implicated as a tumor suppressor. Involved in microtubule-mediated protein transport, but this seems to be due to unregulated mTOR signaling (By similarity).