SUB1 Antikörper (AA 18-47)

Produktnummer ABIN1881856

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch SUB1 in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 4+ Publikationen erwähnt.

Kurzübersicht für SUB1 Antikörper (AA 18-47) (ABIN1881856)

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SUB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40953

Produktdetails anti-SUB1 Antikörper

Bindungsspezifität: AA 18-47

Homologie: Pr

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SUB1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 18-47 amino acids from the Central region of human SUB1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SUB1 Antikörper (ABIN1881856)

Das, Gadad, Kundu: "Human positive coactivator 4 controls heterochromatinization and silencing of neural gene expression by interacting with REST/NRSF and CoREST." in: Journal of molecular biology, Vol. 397, Issue 1, pp. 1-12, (2010) (PubMed).

Rajagopalan, Andreeva, Teufel, Freund, Fersht: "Interaction between the transactivation domain of p53 and PC4 exemplifies acidic activation domains as single-stranded DNA mimics." in: The Journal of biological chemistry, Vol. 284, Issue 32, pp. 21728-37, (2009) (PubMed).

Mortusewicz, Roth, Li, Cardoso, Meisterernst, Leonhardt: "Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites." in: The Journal of cell biology, Vol. 183, Issue 5, pp. 769-76, (2008) (PubMed).

Batta, Kundu: "Activation of p53 function by human transcriptional coactivator PC4: role of protein-protein interaction, DNA bending, and posttranslational modifications." in: Molecular and cellular biology, Vol. 27, Issue 21, pp. 7603-14, (2007) (PubMed).

Details zu SUB1

Target: SUB1 (Activated RNA Polymerase II Transcriptional Coactivator p15 (SUB1))

Andere Bezeichnung: SUB1

Hintergrund: General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).

Molekulargewicht: 14395

NCBI Accession: NP_006704

UniProt: P53999