SMAD5 Antikörper (AA 241-269)

Produktnummer ABIN1881816

Dieses Anti-SMAD5-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SMAD5 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für SMAD5 Antikörper (AA 241-269) (ABIN1881816)

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SMAD5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB40948

Produktdetails anti-SMAD5 Antikörper

Bindungsspezifität: AA 241-269

Homologie: M, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This SMAD5 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 241-269 amino acids from the Central region of human SMAD5.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-SMAD5 Antikörper (ABIN1881816)

Yang, Li, Al-Lamki, Southwood, Zhao, Lever, Grimminger, Schermuly, Morrell: "Smad-dependent and smad-independent induction of id1 by prostacyclin analogues inhibits proliferation of pulmonary artery smooth muscle cells in vitro and in vivo." in: Circulation research, Vol. 107, Issue 2, pp. 252-62, (2010) (PubMed).

Tao, Sampath: "Alternative splicing of SMADs in differentiation and tissue homeostasis." in: Development, growth & differentiation, Vol. 52, Issue 4, pp. 335-42, (2010) (PubMed).

Park, Lee, Ahn, Kim: "Predicting the multi-modal binding propensity of small molecules: towards an understanding of drug promiscuity." in: Molecular bioSystems, Vol. 5, Issue 8, pp. 844-53, (2009) (PubMed).

Middlebrook, Eldin, Li, Shivasankaran, Pangas: "Smad1-Smad5 ovarian conditional knockout mice develop a disease profile similar to the juvenile form of human granulosa cell tumors." in: Endocrinology, Vol. 150, Issue 12, pp. 5208-17, (2009) (PubMed).

Su, Zhu, Han, Feng, Huang, Ren, Pan, Zhang, Lu, Huang: "BMP4-Smad signaling pathway mediates adriamycin-induced premature senescence in lung cancer cells." in: The Journal of biological chemistry, Vol. 284, Issue 18, pp. 12153-64, (2009) (PubMed).

Details zu SMAD5

Target: SMAD5 (SMAD, Mothers Against DPP Homolog 5 (SMAD5))

Andere Bezeichnung: SMAD5

Hintergrund: Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD5 is a receptor-regulated SMAD (R-SMAD).

Molekulargewicht: 52258

NCBI Accession: NP_001001419, NP_001001420, NP_005894

UniProt: Q99717