RRM1 Antikörper (N-Term)

Produktnummer ABIN1881767

Produktdetails anti-RRM1 Antikörper

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Bindungsspezifität: AA 71-100, N-Term

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RRM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This RRM1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 71-100 amino acids from the N-terminal region of human RRM1.

Klon: RB42407

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-RRM1 Antikörper (ABIN1881767)

Ucisik-Akkaya, Davis, Do, Morrison, Stemmer, Amadio, Dorak: "Examination of genetic polymorphisms in newborns for signatures of sex-specific prenatal selection." in: Molecular human reproduction, Vol. 16, Issue 10, pp. 770-7, (2010) (PubMed).

Liu, Wu, Chen, Ter-Minassian, Asomaning, Zhai, Wang, Su, Heist, Kulke, Lin, Liu, Christiani: "A Large-scale genetic association study of esophageal adenocarcinoma risk." in: Carcinogenesis, Vol. 31, Issue 7, pp. 1259-63, (2010) (PubMed).

Details zu RRM1

Target: RRM1 (Ribonucleotide Reductase M1 (RRM1))

Andere Bezeichnung: RRM1 (RRM1 Produkte)

Synonyme: CG5371 antikoerper, DmRNR1 antikoerper, Dmel\\CG5371 antikoerper, RNR1 antikoerper, RnrM1 antikoerper, RntL antikoerper, l(2)k06709 antikoerper, XRRM1 antikoerper, R1 antikoerper, RIR1 antikoerper, RR1 antikoerper, CHUNP6866 antikoerper, cb396 antikoerper, cb838 antikoerper, r1 antikoerper, sb:cb548 antikoerper, wu:fb39b07 antikoerper, wu:fi14b02 antikoerper, wu:fk95f07 antikoerper, ribonucleotide reductase catalytic subunit M1 antikoerper, Ribonucleoside diphosphate reductase large subunit antikoerper, ribonucleoside-diphosphate reductase large subunit antikoerper, ribonucleotide reductase M1 L homeolog antikoerper, ribonucleotide reductase M1 antikoerper, ribonucleotide reductase M1 polypeptide antikoerper, RRM1 antikoerper, RnrL antikoerper, LOC100472317 antikoerper, rrm1 antikoerper, rrm1.L antikoerper, Rrm1 antikoerper

Hintergrund: This gene encodes one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region.

Molekulargewicht: 90070

NCBI Accession: NP_001024

UniProt: P23921

Pathways: Positive Regulation of Endopeptidase Activity