Poliovirus Receptor Antikörper (C-Term)

Produktnummer ABIN1881709

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch Poliovirus Receptor in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für Poliovirus Receptor Antikörper (C-Term) (ABIN1881709)

Target: Poliovirus Receptor (PVR)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Poliovirus Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41981

Produktdetails anti-Poliovirus Receptor Antikörper

Bindungsspezifität: AA 314-342, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PVR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 314-342 amino acids from the C-terminal region of human PVR.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Poliovirus Receptor Antikörper (ABIN1881709)

Nakai, Maniwa, Tanaka, Nishio, Yoshimura, Okita, Ohbayashi, Satoh, Ogita, Takai, Hayashi: "Overexpression of Necl-5 correlates with unfavorable prognosis in patients with lung adenocarcinoma." in: Cancer science, Vol. 101, Issue 5, pp. 1326-30, (2010) (PubMed).

Carlsten, Norell, Bryceson, Poschke, Schedvins, Ljunggren, Kiessling, Malmberg: "Primary human tumor cells expressing CD155 impair tumor targeting by down-regulating DNAM-1 on NK cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 8, pp. 4921-30, (2009) (PubMed).

Kindberg, Ax, Fiore, Svensson: "Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild-type paralytic poliomyelitis." in: Journal of medical virology, Vol. 81, Issue 5, pp. 933-6, (2009) (PubMed).

Details zu Poliovirus Receptor

Target: Poliovirus Receptor (PVR)

Andere Bezeichnung: PVR

Hintergrund: The protein encoded by this gene is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. The external domain mediates cell attachment to the extracellular matrix molecule vitronectin, while its intracellular domain interacts with the dynein light chain Tctex-1/DYNLT1. The gene is specific to the primate lineage, and serves as a cellular receptor for poliovirus in the first step of poliovirus replication. Multiple transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 45303

NCBI Accession: NP_001129240, NP_001129241, NP_001129242, NP_006496

UniProt: P15151

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization, Cancer Immune Checkpoints, SARS-CoV-2 Protein Interaktom