PDE8B Antikörper (AA 296-324)

Produktnummer ABIN1881646

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PDE8B in WB. Er zeigt eine Reaktivität gegenüber Maus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für PDE8B Antikörper (AA 296-324) (ABIN1881646)

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PDE8B Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42219

Produktdetails anti-PDE8B Antikörper

Bindungsspezifität: AA 296-324

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This PDE8B antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 296-324 amino acids from the Central region of human PDE8B.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PDE8B Antikörper (ABIN1881646)

Horvath, Faucz, Finkielstain, Nikita, Rothenbuhler, Almeida, Mericq, Stratakis: "Haplotype analysis of the promoter region of phosphodiesterase type 8B (PDE8B) in correlation with inactivating PDE8B mutation and the serum thyroid-stimulating hormone levels." in: Thyroid : official journal of the American Thyroid Association, Vol. 20, Issue 4, pp. 363-7, (2010) (PubMed).

Shields, Freathy, Knight, Hill, Weedon, Frayling, Hattersley, Vaidya: "Phosphodiesterase 8B gene polymorphism is associated with subclinical hypothyroidism in pregnancy." in: The Journal of clinical endocrinology and metabolism, Vol. 94, Issue 11, pp. 4608-12, (2009) (PubMed).

Bimpaki, Nesterova, Stratakis: "Abnormalities of cAMP signaling are present in adrenocortical lesions associated with ACTH-independent Cushing syndrome despite the absence of mutations in known genes." in: European journal of endocrinology / European Federation of Endocrine Societies, Vol. 161, Issue 1, pp. 153-61, (2009) (PubMed).

Details zu PDE8B

Target: PDE8B (phosphodiesterase 8B (PDE8B))

Andere Bezeichnung: PDE8B

Hintergrund: The protein encoded by this gene is a cyclic nucleotide phosphodiesterase (PDE) that catalyzes the hydrolysis of the second messenger cAMP. The encoded protein, which does not hydrolyze cGMP, is resistant to several PDE inhibitors. Defects in this gene are a cause of autosomal dominant striatal degeneration (ADSD). Several transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht: 98979

NCBI Accession: NP_001025022, NP_001025023, NP_001025024, NP_001025025, NP_003710

UniProt: O95263

Pathways: Negative Regulation of Hormone Secretion, cAMP Metabolic Process