PARK7/DJ1 Antikörper (C-Term)

Produktnummer ABIN1881625

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch PARK7/DJ1 in WB. Er zeigt eine Reaktivität gegenüber Zebrafisch (Danio rerio) und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für PARK7/DJ1 Antikörper (C-Term) (ABIN1881625)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reaktivität: Zebrafisch (Danio rerio)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARK7/DJ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PARK7/DJ1 Antikörper

Bindungsspezifität: AA 120-149, C-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This DANRE park7 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 120-149 amino acids from the C-terminal region of DANRE park7.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-PARK7/DJ1 Antikörper (ABIN1881625)

Bretaud, Allen, Ingham, Bandmann: "p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease." in: Journal of neurochemistry, Vol. 100, Issue 6, pp. 1626-35, (2007) (PubMed).

Bai, Mullett, Garver, Hinkle, Burton: "Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons." in: Brain research, Vol. 1113, Issue 1, pp. 33-44, (2006) (PubMed).

Details zu PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Andere Bezeichnung: park7

Hintergrund: Protects cells against oxidative stress and cell death. May act as an atypical peroxiredoxin-like peroxidase that scavenges hydrogen peroxide. Following removal of a C-terminal peptide, displays protease activity and enhanced cytoprotective action against oxidative stress-induced apoptosis. Binds to a number of mRNAs containing multiple copies of GG or CC motifs and partially inhibits their translation but dissociates following oxidative stress. Required for correct mitochondrial morphology and function and for autophagy of dysfunctional mitochondria. Regulates astrocyte inflammatory responses. Acts as a positive regulator of androgen receptor-dependent transcription. Prevents aggregation of SNCA. Plays a role in fertilization. Has no proteolytic activity. Has cell-growth promoting activity and transforming activity. May function as a redox-sensitive chaperone (By similarity). Protects dopaminergic neurons against cell death arising from oxidative stress and proteasome inhibition, probably by a TP53/p53-dependent mechanism.

Molekulargewicht: 19764

NCBI Accession: NP_001005938

UniProt: Q5XJ36

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport