Neuregulin 3 Antikörper (AA 688-717)

Produktnummer ABIN1881587

Der Kaninchen Polyklonal Anti-Neuregulin 3-Antikörper wurde für WB und IHC (p) validiert. Er ist geeignet, Neuregulin 3 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Neuregulin 3 Antikörper (AA 688-717) (ABIN1881587)

Target: Neuregulin 3 (NRG3)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Neuregulin 3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB2201

Produktdetails anti-Neuregulin 3 Antikörper

Bindungsspezifität: AA 688-717

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This NRG3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 688-717 amino acids of human NRG3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB: 1:1000. IHC-P: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Neuregulin 3 Antikörper (ABIN1881587)

Wansbury, Panchal, James, Parry, Ashworth, Howard: "Dynamic expression of Erbb pathway members during early mammary gland morphogenesis." in: The Journal of investigative dermatology, Vol. 128, Issue 4, pp. 1009-21, (2008) (PubMed).

Zhang, Sliwkowski, Mark, Frantz, Akita, Sun, Hillan, Crowley, Brush, Godowski: "Neuregulin-3 (NRG3): a novel neural tissue-enriched protein that binds and activates ErbB4." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 18, pp. 9562-7, (1997) (PubMed).

Details zu Neuregulin 3

Target: Neuregulin 3 (NRG3)

Andere Bezeichnung: NRG3

Hintergrund: NRG3, which belongs to the neuregulin family, is a direct ligand for the ERBB4 tyrosine kinase receptor. Binding results in ligand-stimulated tyrosine phosphorylation and activation of the receptor. NRG3 does not bind to the EGF receptor, ERBB2 or ERBB3 receptors. The protein exists as an type I membrane protein and as a proteolytically released soluble growth factor form. The membrane-bound form does not appear to be active. NRG3 is highly expressed in most regions of the brain with the exception of corpus callosum, and is expressed at lower level in testis. It is not detected in heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, spleen, thymus, prostate, ovary, small intestine, colon and peripheral blood leukocytes. The NRG3 cytoplasmic domain may be involved in the regulation of trafficking and proteolytic processing. Regulation of the proteolytic processing may involve initial intracellular domain dimerization.

Molekulargewicht: 77901

NCBI Accession: NP_001010848, NP_001159445

UniProt: P56975

Pathways: RTK Signalweg