MTHFR Antikörper (AA 266-292)

Produktnummer ABIN1881559

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch MTHFR in WB. Er zeigt eine Reaktivität gegenüber Human und wurde in 5+ Publikationen erwähnt.

Kurzübersicht für MTHFR Antikörper (AA 266-292) (ABIN1881559)

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MTHFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41196

Produktdetails anti-MTHFR Antikörper

Bindungsspezifität: AA 266-292

Homologie: B, Pr, M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MTHFR antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 266-292 amino acids from the Central region of human MTHFR.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-MTHFR Antikörper (ABIN1881559)

Singh, Singh, Raman: "MTHFR A1298C polymorphism and idiopathic male infertility." in: Journal of postgraduate medicine, Vol. 56, Issue 4, pp. 267-9, (2010) (PubMed).

Harisha, Devi, Christopher, Kruthika-Vinod: "Impact of 5,10-methylenetetrahydrofolate reductase gene polymorphism on neural tube defects." in: Journal of neurosurgery. Pediatrics, Vol. 6, Issue 4, pp. 364-7, (2010) (PubMed).

Wu, Chang, Tsai, Lin, Wang, Tsai, Chen, Yao, Chiu, Bau, Lin: "Significant association of methylenetetrahydrofolate reductase single nucleotide polymorphisms with prostate cancer susceptibility in taiwan." in: Anticancer research, Vol. 30, Issue 9, pp. 3573-7, (2010) (PubMed).

Magnowski, Seremak-Mrozikiewicz, Nowak-Markwitz, Kurzawińska, Drews, Spaczyński: "[No association between MTHFR 677C>T polymorphism and ovarian cancer risk in BRCA1 mutation carriers in Wielkopolska region]." in: Ginekologia polska, Vol. 81, Issue 7, pp. 506-10, (2010) (PubMed).

Kristensen, Pedersen, Melsen, Ellehauge, Mejer: "Variants in the dihydropyrimidine dehydrogenase, methylenetetrahydrofolate reductase and thymidylate synthase genes predict early toxicity of 5-fluorouracil in colorectal cancer patients." in: The Journal of international medical research, Vol. 38, Issue 3, pp. 870-83, (2010) (PubMed).

Details zu MTHFR

Target: MTHFR (Methylenetetrahydrofolate Reductase (NAD(P)H) (MTHFR))

Andere Bezeichnung: MTHFR

Hintergrund: The protein encoded by this gene catalyzes the conversion of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate, a co-substrate for homocysteine remethylation to methionine. Genetic variation in this gene influences susceptibility to occlusive vascular disease, neural tube defects, colon cancer and acute leukemia, and mutations in this gene are associated with methylenetetrahydrofolate reductase deficiency.

Molekulargewicht: 74597

NCBI Accession: NP_005948

UniProt: P42898

Pathways: Methionine Biosynthetic Process