MMP14 Antikörper (C-Term)

Produktnummer ABIN1881546

Dieses Anti-MMP14-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von MMP14 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.

Kurzübersicht für MMP14 Antikörper (C-Term) (ABIN1881546)

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MMP14 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41662

Produktdetails anti-MMP14 Antikörper

Bindungsspezifität: AA 495-523, C-Term

Homologie: M, Pig, Rat

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This MMP14 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 495-523 amino acids from the C-terminal region of human MMP14.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-MMP14 Antikörper (ABIN1881546)

Sakr, Takino, Domoto, Nakano, Wong, Sasaki, Nakanuma, Sato: "GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase." in: Cancer science, Vol. 101, Issue 11, pp. 2368-74, (2010) (PubMed).

Details zu MMP14

Target: MMP14 (Matrix Metallopeptidase 14 (Membrane-inserted) (MMP14))

Andere Bezeichnung: MMP14

Hintergrund: Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily, each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion.

Molekulargewicht: 65894

NCBI Accession: NP_004986

UniProt: P50281

Pathways: Autophagie