ENPP1 Antikörper (N-Term)

Produktnummer ABIN1881296

Der Kaninchen Polyklonal Anti-ENPP1-Antikörper wurde für WB validiert. Er ist geeignet, ENPP1 in Proben von Human zu detektieren. Es sind 5+ Publikationen verfügbar.

Kurzübersicht für ENPP1 Antikörper (N-Term) (ABIN1881296)

Target: ENPP1 (Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ENPP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB41733

Produktdetails anti-ENPP1 Antikörper

Bindungsspezifität: AA 6-34, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ENPP1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 6-34 amino acids from the N-terminal region of human ENPP1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-ENPP1 Antikörper (ABIN1881296)

Ermakov, Rosenbaum, Malkin, Livshits: "Family-based study of association between ENPP1 genetic variants and craniofacial morphology." in: Annals of human biology, Vol. 37, Issue 6, pp. 754-66, (2010) (PubMed).

Wang, Peng, Qu, Huang: "[Association and meta-analysis of ENPP1 K121Q with type 2 diabetes in Han Chinese.]." in: Yi chuan = Hereditas / Zhongguo yi chuan xue hui bian ji, Vol. 32, Issue 8, pp. 808-16, (2010) (PubMed).

Cruz, Valladares-Salgado, Garcia-Mena, Ross, Edwards, Angeles-Martinez, Ortega-Camarillo, de la Peña, Burguete-Garcia, Wacher-Rodarte, Ambriz, Rivera, Dartote, Peralta, Parra, Kumate: "Candidate gene association study conditioning on individual ancestry in patients with type 2 diabetes and metabolic syndrome from Mexico City." in: Diabetes/metabolism research and reviews, Vol. 26, Issue 4, pp. 261-70, (2010) (PubMed).

Moehlecke, Kramer, Leitão, Krahe, Balbosco, Azevedo, Gross, Canani: "[ENPP1 K121Q polymorphism and ischemic heart disease in diabetic patients]." in: Arquivos brasileiros de cardiologia, Vol. 94, Issue 2, pp. 157-61, 168-73, 159-63, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Details zu ENPP1

Target: ENPP1 (Ectonucleotide Pyrophosphatase/phosphodiesterase 1 (ENPP1))

Andere Bezeichnung: ENPP1

Hintergrund: This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance.

Molekulargewicht: 104924

NCBI Accession: NP_006199

UniProt: P22413

Pathways: Regulation of Carbohydrate Metabolic Process