CREB3 Antikörper (N-Term)

Produktnummer ABIN1881228

Dieses Anti-CREB3-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CREB3 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CREB3 Antikörper (N-Term) (ABIN1881228)

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CREB3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: RB42213

Produktdetails anti-CREB3 Antikörper

Bindungsspezifität: AA 66-94, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CREB3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 66-94 amino acids from the N-terminal region of human CREB3.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CREB3 Antikörper (ABIN1881228)

Kim, Choi, Choi, Kang, Kim, Lee, Lee, Lee, Kim, Jun, Jeong, Yoon: "HDAC3 selectively represses CREB3-mediated transcription and migration of metastatic breast cancer cells." in: Cellular and molecular life sciences : CMLS, Vol. 67, Issue 20, pp. 3499-510, (2010) (PubMed).

Audas, Li, Liang, Lu: "A novel protein, Luman/CREB3 recruitment factor, inhibits Luman activation of the unfolded protein response." in: Molecular and cellular biology, Vol. 28, Issue 12, pp. 3952-66, (2008) (PubMed).

Details zu CREB3

Target: CREB3 (CAMP Responsive Element Binding Protein 3 (CREB3))

Andere Bezeichnung: CREB3

Hintergrund: This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds to the cAMP-response element and regulates cell proliferation. The protein interacts with host cell factor C1, which also associates with the herpes simplex virus (HSV) protein VP16 that induces transcription of HSV immediate-early genes. This protein and VP16 both bind to the same site on host cell factor C1. It is thought that the interaction between this protein and host cell factor C1 plays a role in the establishment of latency during HSV infection. This protein also plays a role in leukocyte migration, tumor suppression, and endoplasmic reticulum stress-associated protein degradation. Additional transcript variants have been identified, but their biological validity has not been determined.

Molekulargewicht: 41379

NCBI Accession: NP_006359

UniProt: O43889

Pathways: Thyroid Hormone Synthesis, Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Maintenance of Protein Location, Unfolded Protein Response