CBS Antikörper (N-Term)

Produktnummer ABIN1881141

Dieses Anti-CBS-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von CBS in WB, IF, IHC (p) und FACS. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für CBS Antikörper (N-Term) (ABIN1881141)

Target: CBS (Cystathionine-beta-Synthase (CBS))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CBS Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Flow Cytometry (FACS)

Klon: RB22961

Produktdetails anti-CBS Antikörper

Bindungsspezifität: AA 104-133, N-Term

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This CBS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 104-133 amino acids from the N-terminal region of human CBS.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-CBS Antikörper (ABIN1881141)

Lee, Feliers, Mariappan, Sataranatarajan, Choudhury, Gorin, Kasinath: "Tadalafil Integrates Nitric Oxide-Hydrogen Sulfide Signaling to Inhibit High Glucose-induced Matrix Protein Synthesis in Podocytes." in: The Journal of biological chemistry, Vol. 290, Issue 19, pp. 12014-26, (2015) (PubMed).

Lee, Mariappan, Feliers, Cavaglieri, Sataranatarajan, Abboud, Choudhury, Kasinath: "Hydrogen sulfide inhibits high glucose-induced matrix protein synthesis by activating AMP-activated protein kinase in renal epithelial cells." in: The Journal of biological chemistry, Vol. 287, Issue 7, pp. 4451-61, (2012) (PubMed).

Details zu CBS

Target: CBS (Cystathionine-beta-Synthase (CBS))

Andere Bezeichnung: CBS

Hintergrund: CBS acts as a homotetramer to catalyze the conversion of homocysteine to cystathionine, the first step in the transsulfuration pathway. This protein is allosterically activated by adenosyl-methionine and uses pyridoxal phosphate as a cofactor. Defects in this gene can cause cystathionine beta-synthase deficiency (CBSD), which can lead to homocystinuria.

Molekulargewicht: 60587

NCBI Accession: NP_000062, NP_001171479, NP_001171480

UniProt: P35520