Angiomotin Antikörper (pTyr599)

Produktnummer ABIN1881054

Produktdetails anti-Angiomotin Antikörper

Target: Angiomotin (AMOT)

Bindungsspezifität: pTyr599

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Angiomotin Antikörper ist unkonjugiert

Applikation: Dot Blot (DB)

Homologie: M

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This AMOT Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y599 of human AMOT.

Klon: RB41443

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: DB: 1:500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Haltbarkeit: 6 months

Referenzen für anti-Angiomotin Antikörper (ABIN1881054)

Heller, Adu-Gyamfi, Smith-Kinnaman, Babbey, Vora, Xue, Bittman, Stahelin, Wells: "Amot recognizes a juxtanuclear endocytic recycling compartment via a novel lipid binding domain." in: The Journal of biological chemistry, Vol. 285, Issue 16, pp. 12308-20, (2010) (PubMed).

Bailey, Xie, Do, Montpetit, Diaz, Mohan, Keavney, Yusuf, Gerstein, Engert, Anand: "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study." in: Diabetes Care, Vol. 33, Issue 10, pp. 2250-3, (2010) (PubMed).

Gagné, Moreau, Plourde, Lapointe, Lord, Gagnon, Fernandes: "Human angiomotin-like 1 associates with an angiomotin protein complex through its coiled-coil domain and induces the remodeling of the actin cytoskeleton." in: Cell motility and the cytoskeleton, Vol. 66, Issue 9, pp. 754-68, (2009) (PubMed).

Zheng, Vertuani, Nyström, Audebert, Meijer, Tegnebratt, Borg, Uhlén, Majumdar, Holmgren: "Angiomotin-like protein 1 controls endothelial polarity and junction stability during sprouting angiogenesis." in: Circulation research, Vol. 105, Issue 3, pp. 260-70, (2009) (PubMed).

Talmud, Drenos, Shah, Shah, Palmen, Verzilli, Gaunt, Pallas, Lovering, Li, Casas, Sofat, Kumari, Rodriguez, Johnson, Newhouse, Dominiczak, Samani, Caulfield, Sever, Stanton, Shields, Padmanabhan et al.: "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. ..." in: American journal of human genetics, Vol. 85, Issue 5, pp. 628-42, (2009) (PubMed).

Details zu Angiomotin

Target: Angiomotin (AMOT)

Andere Bezeichnung: AMOT (AMOT Produkte)

Synonyme: C81439 antikoerper, CAG-2 antikoerper, D0Kist1 antikoerper, E230009N18Rik antikoerper, Sii6 antikoerper, mKIAA1071 antikoerper, RGD1564027 antikoerper, si:dkey-13f9.6 antikoerper, wu:fj21a07 antikoerper, angiomotin antikoerper, microRNA 4329 antikoerper, AMOT antikoerper, Amot antikoerper, MIR4329 antikoerper, amot antikoerper

Hintergrund: This gene belongs to the motin family of angiostatin binding proteins characterized by conserved coiled-coil domains and C-terminal PDZ binding motifs. The encoded protein is expressed predominantly in endothelial cells of capillaries as well as larger vessels of the placenta where it may mediate the inhibitory effect of angiostatin on tube formation and the migration of endothelial cells toward growth factors during the formation of new blood vessels. Alternative splicing results in multiple transcript variants encoding different isoforms.

Molekulargewicht: 118085

NCBI Accession: NP_001106962, NP_573572

UniProt: Q4VCS5

Pathways: Cell-Cell Junction Organization, Regulation of Cell Size