LEF1 Antikörper

Produktnummer ABIN187758

Dieses Anti-LEF1-Antikörper ist ein Schaf Polyklonal-Antikörper zur Detektion von LEF1 in WB. Geeignet für Human.

Kurzübersicht für LEF1 Antikörper (ABIN187758)

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Reaktivität: Human

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser LEF1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-LEF1 Antikörper

Spezifität: Antibody reacts with human LEF-1, TCF-1, TCF-3, and TCF-4 Species Reactivity: Human, other species not tested.

Immunogen: Full length LEF

Anwendungsinformationen

Applikationshinweise: Western blot: Use at 1-5 µg/ml The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mg/ml purified IgG in PBS with 0.02% sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu LEF1

Target: LEF1 (Lymphoid Enhancer-Binding Factor 1 (LEF1))

Andere Bezeichnung: LEF1

Hintergrund: Lymphoid Enhancer Factor - 1 is a transcription factor of the High Mobility Group of DNA binding proteins. It is one member of a family of four proteins referred to as LEF/TCF transcription factors (LEF-1, TCF-1, TCF-3, and TCF-4) These factors play a crucial role in WNT/Wingless signaling, a transduction cascade that directs cell differentiation. Aberrant activation of the WNT/Wingless pathway is also involved in the genesis of some cancers, including colon cancer, melanoma, and breast cancer. LEF-1 is expressed during development in many differentiating tissues, and in a few tissues after birth. LEF-1 expression is required for proper development of breast, teeth, hair, whiskers, and the trigeminal nerve. It is redundant with TCF-1 (T Cell Factor-1) for correct development of T lymphocytes in the thymus. LEF-1 is a 399 amino acid protein that appears as a cluster of polypeptides ranging in size between 55-57 kD on SDS-PAGE gels. Alternative splice forms of LEF-1 and other LEF/TCF family members have been identified, but the expression pattern and relative abundance of these alternative forms have not been well studied. They may appear on Western blots as smaller immunoreactive forms.

Pathways: WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Hormone Metabolic Process, Nuclear Hormone Receptor Binding, Chromatin Binding