BAFF Antikörper

Produktnummer ABIN187404

Der Ratte Monoklonal anti-BAFF Antikörper (Klon Buffy-1) (ABIN187404) detektiert spezifisch BAFF in WB und FACS. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BAFF Antikörper (ABIN187404)

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser BAFF Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Klon: Buffy-1

Produktdetails anti-BAFF Antikörper

Spezifität: Recognizes the stalk region present in the membrane-bound form of human BAFF. Species Reactivity: Human, others not tested.

Immunogen: Human sol. BAFF (rec., aa. 83-285)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: optimal concentration range is 0.5-5 µg/ml. Western blotting The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/ml. Purity > 95% as determined by SDS-PAGE. The antibody was purified from concentrated hybridoma cell culture supernatant.

Buffer: 100 µg in PBS and 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu BAFF

Target: BAFF (TNFSF13B) (Tumor Necrosis Factor (Ligand) Superfamily, Member 13b (TNFSF13B))

Andere Bezeichnung: CD257 / BAFF

Hintergrund: BAFF (for B-cell activating factor belonging to the TNF family), a new member of the tumor necrosis factor (TNF) family was simultaneously identified by four different laboratories and named BAFF, TALL-1, THANK, zTNF4. It is abundantly expressed in monocytes and macrophages, upregulated by interferon gamma. Endogenous BAFF is processed intracellularly by a protease of the furin family of proprotein convertases. Secreted BAFF acts as a potent B cell growth factor. Recently, two receptors for BAFF have been identified and termed as BCMA and TACI.

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response