Myeloperoxidase Antikörper

Produktnummer ABIN187335

Dieser Anti-Myeloperoxidase Antikörper ist ein Maus Monoklonal Antikörper zur Detektion von Myeloperoxidase in FACS und IHC (fro). Geeignet für Human und Ratte.

Kurzübersicht für Myeloperoxidase Antikörper (ABIN187335)

Target: Myeloperoxidase (MPO)

Reaktivität: Human, Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Myeloperoxidase Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 8F4

Produktdetails anti-Myeloperoxidase Antikörper

Spezifität: Monoclonal antibody 8F4 reacts with MPO. Species Reactivity: Human and rat. Others not tested.

Sterilität: 0.2 μm filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: The typical starting dilution is 1:10. Immunohistochemistry: (Frozen sections)-The typical starting dilution is 1:10. The optimal dilution for a specific application should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 ml containing 100 µg IgG in PBS with 0.1% BSA. The antibody solution was filtered through a 0.2 micron filter.

Lagerung: 4 °C

Details zu Myeloperoxidase

Target: Myeloperoxidase (MPO)

Andere Bezeichnung: Myeloperoxidase

Hintergrund: Myeloperoxidase (MPO) is a glycoprotein with an alpha2beta2 heteromultimer expressed in all cells of the myeloid lineage. MPO is abundantly present in azurophilic granules of polymorphonuclear neutrophils. It is an important enzyme used during phagocytic lysis of engulfed foreign particles which takes part in the defense of the organism through production of hypochlorous acid (HOCl), a potent oxidant. MPO is rapidly released by activated polymorphonuclear neutrophils. Involvement of MPO has been described in numerous diseases such as atherosclerosis, lung cancer, Alzheimer's disease and multiple sclerosis. Autoimmune antibodies to MPO are involved in Wegeners disease. Since the discovery of MPO deficiency, initially regarded as rare and restricted to patients suffering from severe infections, MPO has attracted more clinical attention. In experimental studies antibodies to MPO can be used for various purposes ranging from flow cytometric analysis to detection of polymorphonuclear neutrophils in tissue sections.

Pathways: Chromatin Binding