Der Maus Monoklonal anti-RUNX3 Antikörper wird verwendet zum Nachweis von RUNX3 in Proben von Human und Maus. Er wurde validiert für WB, ELISA, IHC, FACS und IF/ICC.
This gene encodes a member of the runt domain-containing family of transcription factors.A heterodimer of this protein and a beta subunit forms a complex that binds to the core DNA sequence 5'-PYGPYGGT-3' found in a number of enhancers and promoters, and can either activate or suppress transcription.It also interacts with other transcription factors.It functions as a tumor suppressor, and the gene is frequently deleted or transcriptionally silenced in cancer.Multiple transcript variants encoding different isoforms have been found for this gene.