CD33 Antikörper (AA 15-237)
Kurzübersicht für CD33 Antikörper (AA 15-237) (ABIN1845398)
Target
Alle CD33 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 15-237
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Aufreinigung
- Purified antibody
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Immunogen
- Purified recombinant fragment of human CD33 (AA: 15-237) expressed in E. coli.
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Isotyp
- IgG1
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Applikationshinweise
- Optimal working dilution should be determined by the investigator.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1.0 mg/mL
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Buffer
- PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- -20 °C
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Informationen zur Lagerung
- Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.
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- CD33
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Andere Bezeichnung
- CD33
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Hintergrund
- The protein encoded by this gene belongs to putative adhesion molecule of myelomonocytic-derived cells that mediates sialic-acid dependent binding to cells.Preferentially binds to alpha-2,6-linked sialic acid.The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface.In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase (s) via their SH2 domain (s) that block signal transduction through dephosphorylation of signaling molecules.Induces apoptosis in acute myeloid leukemia (in vitro) and CD33 plays potential key roles in the pathogenesis of Alzheimer's disease (AD).
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Molekulargewicht
- 39.8 kDa
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Gen-ID
- 945
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UniProt
- P20138
Target
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