INCENP Antikörper (AA 369-583)

Produktnummer ABIN1844019

Dieses Anti-INCENP-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von INCENP in WB, FACS, ELISA, IHC und IF/ICC. Geeignet für Human.

Kurzübersicht für INCENP Antikörper (AA 369-583) (ABIN1844019)

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser INCENP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), ELISA, Immunohistochemistry (IHC), Immunofluorescence (fixed cells) (IF/ICC)

Produktdetails anti-INCENP Antikörper

Bindungsspezifität: AA 369-583

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human INCENP (AA: 369-583) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: PBS with 0.05 % sodium azide and 0.5 % protein stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Aliquot and store at -20 °C. Avoid repeated freeze/thaw cycles.

Details zu INCENP

Target: INCENP (Inner Centromere Protein Antigens 135/155kDa (INCENP))

Andere Bezeichnung: INCENP

Hintergrund: In mammalian cells, 2 broad groups of centromere-interacting proteins have been described: constitutively binding centromere proteins and 'passenger,' or transiently interacting, proteins (reviewed by Choo, 1997). The constitutive proteins include CENPA (centromere protein A, MIM 117139), CENPB (MIM 117140), CENPC1 (MIM 117141), and CENPD (MIM 117142). The term 'passenger proteins' encompasses a broad collection of proteins that localize to the centromere during specific stages of the cell cycle (Earnshaw and Mackay, 1994 [PubMed 8088460]). These include CENPE (MIM 117143), MCAK (MIM 604538), KID (MIM 603213), cytoplasmic dynein (e.g., MIM 600112), CliPs (e.g., MIM 179838), and CENPF/mitosin (MIM 600236). The inner centromere proteins (INCENPs) (Earnshaw and Cooke, 1991 [PubMed 1860899]), the initial members of the passenger protein group, display a broad localization along chromosomes in the early stages of mitosis but gradually become concentrated at centromeres as the cell cycle progresses into mid-metaphase. During telophase, the proteins are located within the midbody in the intercellular bridge, where they are discarded after cytokinesis.

Molekulargewicht: 105.4 kDa

Gen-ID: 3619

UniProt: Q9NQS7

Pathways: Zellzyklus