TBP Antikörper (Middle Region)

Produktnummer ABIN184358

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-TBP Antikörper wird verwendet zum Nachweis von TBP in Proben von Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Hund, Kaninchen, Schaf und Meerschweinchen. Er wurde validiert für WB.

Kurzübersicht für TBP Antikörper (Middle Region) (ABIN184358)

Target: TBP (TATA Box Binding Protein (TBP))

Reaktivität: Human, Maus, Ratte, Rind (Kuh), Zebrafisch (Danio rerio), Hund, Kaninchen, Schaf, Meerschweinchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TBP Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-TBP Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: TBP Antibody - middle region

Sequenz: FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD

Kreuzreaktivität: Rind (Kuh), Hund, Huhn, Human, Maus, Ratte (Rattus)

Homologie: Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%

Produktmerkmale: This is a rabbit polyclonal antibody against TBP. It was validated on Western Blot using a cell lysate as a positive control.

Aufreinigung: Protein A purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human TBP

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Referenzen für anti-TBP Antikörper (ABIN184358)

Reid, van Roon-Mom, Wood, Rees, Owen, Faull, Dragunow, Snell: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." in: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).

Details zu TBP

Target: TBP (TATA Box Binding Protein (TBP))

Andere Bezeichnung: TBP

Hintergrund:

Background Information: Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.

Gene Name: TATA box binding protein

Alternative Symbols: HDL4, GTF2D, SCA17, TFIID, GTF2D1

Protein Name: TATA-box-binding protein

Molekulargewicht: 38kDa

Gen-ID: 6908

NCBI Accession: NP_003185

UniProt: P20226

Pathways: WNT Signalweg