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TBP Antikörper (Middle Region)

TBP Reaktivität: Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Kaninchen, Schaf, Meerschweinchen WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN184358
  • Target Alle TBP Antikörper anzeigen
    TBP (TATA Box Binding Protein (TBP))
    Bindungsspezifität
    • 15
    • 6
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Middle Region
    Reaktivität
    • 71
    • 43
    • 39
    • 7
    • 7
    • 6
    • 5
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Human, Maus, Ratte, Rind (Kuh), Hund, Zebrafisch (Danio rerio), Kaninchen, Schaf, Meerschweinchen
    Wirt
    • 51
    • 20
    • 2
    Kaninchen
    Klonalität
    • 51
    • 22
    Polyklonal
    Konjugat
    • 53
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser TBP Antikörper ist unkonjugiert
    Applikation
    • 66
    • 29
    • 14
    • 13
    • 13
    • 12
    • 11
    • 9
    • 9
    • 5
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Sequenz
    FSSGKMVCTG AKSEEQSRLA ARKYARVVQK LGFPAKFLDF KIQNMVGSCD
    Kreuzreaktivität
    Rind (Kuh), Hund, Huhn, Human, Maus, Ratte (Rattus)
    Homologie
    Cow: 100%, Dog: 100%, Guinea Pig: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
    Produktmerkmale
    This is a rabbit polyclonal antibody against TBP. It was validated on Western Blot using a cell lysate as a positive control.
    Aufreinigung
    Protein A purified
    Immunogen
    The immunogen is a synthetic peptide directed towards the middle region of human TBP
    Top Product
    Discover our top product TBP Primärantikörper
  • Applikationshinweise
    WB Suggested Anti-TBP Antibody Titration: 2.5 µg/mL
    Positive Control: Human Placenta.
    Optimal working dilutions should be determined experimentally by the investigator.
    Kommentare

    Antigen size: 339 AA

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    Lot specific
    Buffer
    Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Avoid repeated freeze-thaw cycles.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
  • Reid, van Roon-Mom, Wood, Rees, Owen, Faull, Dragunow, Snell: "TBP, a polyglutamine tract containing protein, accumulates in Alzheimer's disease." in: Brain research. Molecular brain research, Vol. 125, Issue 1-2, pp. 120-8, (2004) (PubMed).

  • Target
    TBP (TATA Box Binding Protein (TBP))
    Andere Bezeichnung
    TBP (TATA-box-binding protein) (TBP Produkte)
    Synonyme
    GTF2D antikoerper, GTF2D1 antikoerper, HDL4 antikoerper, SCA17 antikoerper, TFIID antikoerper, Gtf2d antikoerper, fd20h06 antikoerper, si:zc101n13.2 antikoerper, wu:fd20h06 antikoerper, zgc:66213 antikoerper, TBP1 antikoerper, TBP antikoerper, tbp antikoerper, CG9874 antikoerper, Dmel\\CG9874 antikoerper, RBP antikoerper, TBP38 antikoerper, TFIIDtau antikoerper, TfIID antikoerper, dTBP antikoerper, dTFIID antikoerper, dTbp antikoerper, dtbp antikoerper, gtf2d antikoerper, gtf2d1 antikoerper, sca17 antikoerper, tfiid antikoerper, tfiidtau antikoerper, xtbp antikoerper, tbp-a antikoerper, tbp-b antikoerper, TATA-box binding protein antikoerper, TATA box binding protein antikoerper, TATA binding protein antikoerper, TATA-box binding protein L homeolog antikoerper, TATA-box-binding protein antikoerper, TATA-box binding protein S homeolog antikoerper, TBP antikoerper, Tbp antikoerper, tbp antikoerper, tbp.L antikoerper, tbp.S antikoerper
    Hintergrund
    Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes TBP, the TATA-binding protein. A distinctive feature of TBP is a long string of glutamines in the N-terminal. This region of the protein modulates the DNA binding activity of the C terminus, and modulation of DNA binding affects the rate of transcription complex formation and initiation of transcription. Mutations that expand the number of CAG repeats encoding this polyglutamine tract, and thus increase the length of the polyglutamine string, are associated with spinocerebellar ataxia 17, a neurodegenerative disorder classified as a polyglutamine disease.
    Alias Symbols: HDL4, GTF2D, SCA17, TFIID, GTF2D1
    Protein Interaction Partner: DR1, SSX2IP, GOLGA2, MEF2A, TAF8, GNG12, GNB2, UBC, UBE2I, TAF10, TAF5, HNF4A, E2F1, PAX5, TAF1A, TCEA1, RUVBL2, Abt1, GTF2A2, ICE2, tat, MED26, TBP, TAF6, TAF4, TAF1, SP1, TP53, SNAPC2, SNAPC1, MUC1, Taf1c, Taf1b, GTF2B, HCVgp1, AHR, TAF9B, BTAF1, TAF13,
    Protein Size: 339
    Molekulargewicht
    38 kDa
    Gen-ID
    6908
    NCBI Accession
    NM_003194, NP_003185
    UniProt
    P20226
    Pathways
    WNT Signalweg
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