B-Cell Linker Antikörper (AA 171-356)

Produktnummer ABIN1838325

Dieses Anti-B-Cell Linker-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von B-Cell Linker in WB. Geeignet für Human.

Kurzübersicht für B-Cell Linker Antikörper (AA 171-356) (ABIN1838325)

Target: B-Cell Linker (BLNK)

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser B-Cell Linker Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-B-Cell Linker Antikörper

Bindungsspezifität: AA 171-356

Spezifität: BLNK (B cell linker protein) is an adaptor molecule that plays key role in B cell activation initiated by cross-linking the B cell receptor (BCR). This activation leads to an increase in the tyrosine phosphorylation of a number of proteins due to activation of nonreceptor protein tyrosine kinases (PTK) including Syk, which is responsible for the tyrosine phosphorylation of BLNK. BLNK is cytosolic protein identified as two phosphoproteins migrating at 68 and 70 kD in SDS/PAGE (alternatively spliced forms of human BLNK). Mapping of the tyrosine residues in BLNK reveal three tyrosines that bind PLC-gamma2, and two tyrosines that bind the Tec family kinase Btk, the Vav nucleotide exchange factor and the adaptor Nck.

Aufreinigung: Purified

Immunogen: A fusion protein representing amino acids 171-356 of human BLNK.

Type of Immunogen: Fusion protein

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS,  pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term: 4°C. Long term: Store at -20°C. Avoid freeze-thaw cycles.

Details zu B-Cell Linker

Target: B-Cell Linker (BLNK)

Andere Bezeichnung: BLNK

Hintergrund: Name/Gene ID: BLNK
Family: Signal Transduction

Synonyms: BLNK, AGM4, BLNK-S, B-cell activation, B-cell linker protein, B cell linker protein, Bca, Cytoplasmic adapter protein, LY57, SLP-65, SLP65, B-cell linker, BASH

Gen-ID: 29760

UniProt: Q8WV28

Pathways: BCR Signaling