Lipoprotein Lipase Antikörper (AA 380-410) (Biotin)

Produktnummer ABIN1820142

Dieses Anti-Lipoprotein Lipase-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Lipoprotein Lipase in WB, IP und ELISA. Geeignet für Human, Ratte, Rind (Kuh), Huhn, Meerschweinchen und Schwein.

Kurzübersicht für Lipoprotein Lipase Antikörper (AA 380-410) (Biotin) (ABIN1820142)

Target: Lipoprotein Lipase (LPL)

Reaktivität: Human, Ratte, Rind (Kuh), Huhn, Meerschweinchen, Schwein

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Lipoprotein Lipase Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), Immunoprecipitation (IP), ELISA

Klon: 5D2

Produktdetails anti-Lipoprotein Lipase Antikörper (Biotin)

Bindungsspezifität: AA 380-410

Spezifität: Recognizes an epitope within amino acids 380-410 of lipoprotein lipase (LPL), a member of the AB hydrolase superfamily, which plays a pivotal role in lipoprotein metabolism and transport, acting as the key enzyme in the hydrolysis of triglycerides and very low density lipoproteins (VLDLs), and the release of free fatty acids into peripheral tissues. A deficiency of LPL can result in hypertriglyceridemia, and many studies have focused on the critical role which LPL plays in the pathogenesis of atherosclerosis, and in particular the relationship between LPL and apolipoprotein E (ApoE), both of which are secreted in significant amounts by macrophages in developing arterial wall lesions. Clone 5D2 is a unique antibody which differentiates between monomeric inactive and dimeric active LPL, and binds to LPL sequences involved in LPL, LPL receptor, and heparin interactions. Clone 5D2 has been shown to inhibit the activity of human LPL(2,3), and is widely used in human studies.

Keine Kreuzreaktivität: Maus

Aufreinigung: Protein G purified

Immunogen: Purified bovine milk lipoprotein lipase.

Type of Immunogen: Purified protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (1:50 - 1:200), IP, WB

Usage: The applications listed have been tested for the unconjugated form of this product. Other forms have not been tested.

Kommentare:

Target Species of Antibody: Bovine

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide, 1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu Lipoprotein Lipase

Target: Lipoprotein Lipase (LPL)

Andere Bezeichnung: Lipoprotein Lipase / LPL

Hintergrund: Name/Gene ID: LPL

Synonyms: LPL, LIPD, Lipoprotein lipase, HDLCQ11

Gen-ID: 4023

UniProt: P06858

Pathways: Lipid Metabolism