APOE Antikörper (AA 140-160)

Produktnummer ABIN1820139

Produktdetails anti-APOE Antikörper

Target: APOE (Apolipoprotein E (APOE))

Bindungsspezifität: AA 140-160

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser APOE Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Spezifität: Recognizes an epitope within amino acids 140-160 of human apolipoprotein E (Apo-E), a major component of very low-density lipoproteins (VLDLs). Apo-E is the principle apolipoprotein in the central nervous system, and is secreted by most organs into the plasma, playing a vital role in the binding, internalization and catabolism of triglyceride-rich lipoprotein constituents. Apo-E acts as a ligand for both the specific apo-E receptor (chylomicron remnant) of hepatic tissues, and the apoB, E (LDL) receptor. Three isoforms of Apo-E have been identified, ApoE2, E3 and E4, and have been linked with various disorders. ApoE2 has been shown to bind LPL receptors with low affinity, resulting in increased plasma cholesterol and triglyceride levels, and thereby an increased risk in cardiovascular disorders. ApoE4 is a known high risk factor for Alzheimer's disease, and in particular late onset Alzheimer disease 2 (AD2), whilst ApoE3 is the most common isoform, and considered the normal/natural Apo-E genotype. Clone 6-4 has been shown to inhibit Apo-E mediated binding of lipoproteins to the apoB, E cell receptor.

Aufreinigung: Protein G purified

Immunogen: Purified ApoHDL fraction.

Type of Immunogen: Purified protein

Klon: WUE-4

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA (1:100 - 1:1000), WB

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu APOE

Target: APOE (Apolipoprotein E (APOE))

Andere Bezeichnung: APOE / Apolipoprotein E (APOE Produkte)

Synonyme: ad2 antikoerper, apoprotein antikoerper, im:7036787 antikoerper, wu:fb69a05 antikoerper, zgc:110064 antikoerper, apoe antikoerper, AI255918 antikoerper, AD2 antikoerper, LDLCQ5 antikoerper, LPG antikoerper, APOEA antikoerper, Apo-E antikoerper, apolipoprotein E antikoerper, apolipoprotein Ea antikoerper, apoe antikoerper, apoea antikoerper, Apoe antikoerper, APOE antikoerper

Hintergrund: Name/Gene ID: APOE

Synonyms: APOE, AD2, Apo-E, Apolipoprotein E3, Apolipoprotein E, LDLCQ5, LPG

Gen-ID: 348

UniProt: P02649

Pathways: Regulation of Cell Size, Lipid Metabolism