PRKAA1 Antikörper (N-Term)

Produktnummer ABIN1819880

Der Maus Monoklonal Anti-PRKAA1-Antikörper wurde für WB, IHC, ELISA, IF, IP und IHC (fro) validiert. Er ist geeignet, PRKAA1 in Proben von Human, Maus, Ratte, Drosophila melanogaster und Vertebrate zu detektieren.

Kurzübersicht für PRKAA1 Antikörper (N-Term) (ABIN1819880)

Target: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Reaktivität: Human, Maus, Ratte, Drosophila melanogaster, Vertebrate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PRKAA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: 34-2

Produktdetails anti-PRKAA1 Antikörper

Bindungsspezifität: N-Term

Spezifität: Recognizes both the alpha 1 and the alpha 2 isoforms of AMP-activated protein kinase (AMPK). AMPK is a highly conserved heterotrimeric protein kinase found in all eukaryotes. The heterotrimeric complex exists as multiple isoforms and consists of a catalytic alpha subunit, which is stabilized by non-catalytic regulatory beta- and gamma- subunits. AMPK plays a vital role in maintaining cellular energy homeostasis and is activated by rising levels of AMP under conditions of hypoxia, ischemia, exercise, low glucose levels. AMPK may play an important role in the control of type 2 diabetes and metabolic syndromes. Recent studies suggest that AMPK functions as a suppressor of cell proliferation of both malignant and normal cells.

Aufreinigung: Protein G purified

Immunogen: 29 amino acid peptide within the N-terminal catalytic domain of Drosophila AMPK alpha.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, IF, IHC, IHC-Fr, IP, WB (1:100 - 1:1000)

Kommentare:

Target Species of Antibody: Drosophila

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS, 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: 4°C or -20°C, Avoid freeze-thaw cycles.

Details zu PRKAA1

Target: PRKAA1 (Protein Kinase, AMP-Activated, alpha 1 Catalytic Subunit (PRKAA1))

Andere Bezeichnung: PRKAA1 / AMPK Alpha 1

Hintergrund: Name/Gene ID: PRKAA1
Subfamily: AMPK/SNF1
Family: Protein Kinase

Synonyms: PRKAA1, ACACA kinase, AMPK alpha 1, AMPK alpha-1 chain, Acetyl-CoA carboxylase kinase, AMPKa1, AMPK subunit alpha-1, AMPK, AMPK1, Tau-protein kinase PRKAA1, HMGCR kinase

Gen-ID: 5562

UniProt: Q13131

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt