This antibody reacts to Collagen V. This antibody shows less than 10 % reactivity with collagen type I, II, III, IV, and VI. It may react with collagen V from other species. Reactivity with other ECM proteins has not been tested.
ELISA. Immunoblotting. Immunofluorescence. Immunohistochemistry on frozen sections. Other applications not tested. Optimal dilutions are dependent on conditions and should be determined by the user.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Konzentration
0.4 mg/mL
Buffer
Borate buffered saline
Handhabung
Avoid repeated freezing and thawing.
Lagerung
-20 °C
Target
Collagen Type V (COL5)
(Collagen, Type V (COL5))
Andere Bezeichnung
Collagen Type V
Hintergrund
Type V Collagen is a member of group I Collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V Collagen binds to DNA, heparan sulfate, Thrombospondin, Heparin, and Insulin. Collagen V is composed of several subunits as follows: trimers of two alpha 1(V) and one alpha 2(V) chains in most tissues and trimers of one alpha 1(V), one alpha 2(V), and one alpha 3(V) chains in placenta. Type V Collagen is closely related to type XI Collagen and it is possible that the Collagen chains of types V and XI constitute a single collagen type with tissue specific chain combinations. Mutations in this gene are associated with Ehlers Danlos syndrome, types I and II.Synonyms: COL5A1