IL-11 Antikörper

Produktnummer ABIN181144

Dieses Maus Monoklonal-Antikörper erkennt spezifisch IL-11 in WB, EIA und Func. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für IL-11 Antikörper (ABIN181144)

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser IL-11 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)

Produktdetails anti-IL-11 Antikörper

Spezifität: This antibody detects Human Interleukin-11. Other species not tested.

Produktmerkmale: Synonyms: IL-11, Adipogenesis inhibitory factor, AGIF

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Highly pure (>98%) recombinant Human IL-11

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Neutralisation: To yield one-half maximal inhibition [ND50] of the biological activity ofhIL-11 (5.0 ng/mL), a concentration of 2.4-3.6 μg/mL is required. ELISA: In a sandwich ELISA (assuming 100 μL/well), a concentration of 8-9 μg/mL will detectat least 0.2 ng/well of recombinant Human IL-11 when used with Biotin anti-Human IL-11antibody (cat. PP1033B) as the detection antibody at a concentration of at least 2 μg/mL. Western Blot: To detect hIL-11 by Western Blot analysis this antibody can be used at aconcentration of 1.0-2.0 μg/mL. Used in conjunction with compatible secondary reagentsthe detection limit for recombinant hIL-11 is 0.25-0.50 ng/lane, under non-reducingconditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore in sterile water to a concentration of 1.0 mg/mL.

Buffer: PBS without preservatives

Konservierungsmittel: Without preservative

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The lyophilized antibody is stable at room temperature for one month or at -20 °C forlonger. Following reconstitution it is stable at 2 - 8 °C for six weeks. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu IL-11

Target: IL-11 (IL11) (Interleukin 11 (IL11))

Andere Bezeichnung: Interleukin-11 / IL11

Hintergrund: Interleukin 11 is a pleiotropic cytokine produced by mesenchymal-derived adherent cells. IL11 shares many functions of IL6 and LIF, including potentiation of megakaryocyte activity, enhancement of human myeloma cell proliferation, and enhancement of hepatic acute phase protein production. Interleukin 11 directly stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells, and induces megakaryocyte maturation resulting in increased platelet production. Clinically it is used to prevent severe thrombocytopenia and the reduction of the need for platelet transfusion following myelosuppressive chemotherapy.Synonyms: AGIF, Adipogenesis inhibitory factor, IL-11

Gen-ID: 3589

UniProt: P20809

Pathways: JAK-STAT Signalweg, Negative Regulation of Hormone Secretion