C5 Antikörper

Produktnummer ABIN181110

Dieses Anti-C5-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von C5 in WB, EIA und Func. Geeignet für Human.

Kurzübersicht für C5 Antikörper (ABIN181110)

Target: C5 (Complement Component 5 (C5))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Functional Studies (Func)

Klon: 10-04-14

Produktdetails anti-C5 Antikörper

Spezifität: This antibody recognizes secreted complement component 5 (C5), a 190 kDa serine protease present in blood serum. In haemolysis inhibition studies it was found that this antibody will block C5 haemolytic activity. Removal of Sodium Azide is recommended prior to use in Functional Assays.

Produktmerkmale: Synonyms: CPAMD4, Complement component 5, C3 and PZP-like alpha-2-macroglobulindomain-containing protein 4

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Purified human C5Genename: C5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA. Western Blot. Functional Assays.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Borate buffered saline, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu C5

Target: C5 (Complement Component 5 (C5))

Andere Bezeichnung: Complement C5

Hintergrund: It is composed of an 115 kDa disulphide linked alpha-chain and a 75 kDa beta-chain. In addition to its role in complement, C5 is thought to be associated with inflammation, stimulating tumour necrosis factor alpha, interferon gamma mediated suppression of IL10 and IL12 production. C5 is activated via either the classical or the alternative complement pathway, by proteolytic cleavage of C5a from the N-terminal of the alpha-chain, by C5 convertase. C5a is an anaphylotoxin which mediates local inflammation. It induces the contraction of smooth muscle, increases vascular permeability and causes histamine release from mast cells and basophilic leukocytes. It also stimulates chemotaxis of neutrophils, eosinophils, basophils and monocytes towards the site of inflammation. The remaining fragment, C5b, initiates the assembly of the membrane attack complex.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, CPAMD4, Complement component 5

Gen-ID: 727

UniProt: P01031

Pathways: Komplementsystem, Carbohydrate Homeostasis