Complement C4A/C4B Antikörper

Produktnummer ABIN181108

Produktdetails

Target: Complement C4A/C4B

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Flow Cytometry (FACS)

Spezifität: This antibody recognises complement component 4c (C4c).

Produktmerkmale: Synonyms: Complement Component 4, CPAMD2, CPAMD3

Aufreinigung: Affinity chromatography on Protein A

Immunogen: Purified human C4c. Genename: C4c

Klon: 10-12-14

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot. Flow Cytometry. ELISA: This antibody binds both C4c and C4 and so is not suitable for all ELISAapplications. Immunohistochemistry on frozen sections. Recommended Postive Control: Kidney sections from post-streptococal glomerulonephritispastients.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0mg/mL

Buffer: Borate buffered saline, pH 8.4 containing 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Antigendetails

Target: Complement C4A/C4B

Synonyme: C4 antikoerper, C4-1 antikoerper, C4b antikoerper, complement component 4A (Rodgers blood group) antikoerper, C4a antikoerper

Hintergrund: The complement 1 complex cleaves complement 4 (C4) to form C4b and C4a. C4b levels are strictly regulated. Single site cleavage of the C4bs alpha chain by Factor I forms iC4b and blocks C3 convertase, inhibiting opsonisation and activation of the classical pathway. iC4b is further degraded into the inactive fragments C4d and C4c. C4c consists of two a-chain fragments, alpha 4 (13 kDa) and alpha 3 (25 kDa) linked to a beta chain through disulphide bridges and a gamma chain. It is expressed in the blood plasma.Synonyms: CPAMD2, CPAMD3, Complement Component 4

Gen-ID: 720

UniProt: P0C0L4