PARK7/DJ1 Antikörper (N-Term)

Produktnummer ABIN1737863

Der Kaninchen Polyklonal Anti-PARK7/DJ1-Antikörper wurde für WB validiert. Er ist geeignet, PARK7/DJ1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für PARK7/DJ1 Antikörper (N-Term) (ABIN1737863)

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PARK7/DJ1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PARK7/DJ1 Antikörper

Bindungsspezifität: AA 167-189, N-Term

Spezifität: Reacts with human and mouse PARK7. Sequence homology to mouse and rat DJ-1 is 82 % .

Aufreinigung: Purified

Immunogen: Synthetic peptide corresponding to amino acids 167-189 (AIVEALNGKEVAAQVKAPLVLKD) of human PARK7 conjugated to KLH at the N-terminus.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB1:500

Positive control: HEK293 cell lysate or mouse brain tissue lysate

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.4,

Handhabung: Dilute in PBS or medium which is identical to that used in the assay system.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Short term storage at+4°C. For extended periods store in aliquots at -20°C. Antibodies are guaranteed for 6 months from date of receipt.

Haltbarkeit: 6 months

Details zu PARK7/DJ1

Target: PARK7/DJ1 (PARK7) (Parkinson Protein 7 (PARK7))

Andere Bezeichnung: Park7

Hintergrund: Park7/DJ-1 is one of several genes thought to cause autosomal-recessive early-onset parkinsonism. Protects cells against oxidative stress and cell death. Plays a role in regulating expression or stability of the mitochondrial uncoupling proteins SLC25A14 and SLC25A27 in dopaminergic neurons of the substantia nigra pars compacta and attenuates the oxidative stress induced by calcium entry into the neurons via L-type channels during pacemaking. Eliminates hydrogen peroxide and protects cells against hydrogen peroxide-induced cell death.

Protein DJ-1 Oncogene DJ1 Parkinson disease protein 7 Gene name: PARK7

Gen-ID: 11315

UniProt: Q99497

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Proton Transport