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APAF1 Antikörper (AA 12-28)

APAF1 Reaktivität: Human, Maus WB, IHC (p), IF, ICC Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN1731834
  • Target Alle APAF1 Antikörper anzeigen
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Bindungsspezifität
    • 16
    • 15
    • 9
    • 8
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 12-28
    Reaktivität
    • 84
    • 51
    • 49
    • 15
    • 1
    Human, Maus
    Wirt
    • 70
    • 9
    • 7
    • 1
    Kaninchen
    Klonalität
    • 63
    • 24
    Polyklonal
    Konjugat
    • 43
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser APAF1 Antikörper ist unkonjugiert
    Applikation
    • 52
    • 27
    • 26
    • 26
    • 20
    • 15
    • 14
    • 13
    • 12
    • 11
    • 9
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF), Immunocytochemistry (ICC)
    Spezifität
    Reacts with human and mouse Apaf1.
    Aufreinigung
    Purified
    Immunogen
    Synthetic peptide, corresponding to amino acids 12-28 of Human Apaf 1. The sequence of the immunogenic peptide differs from that of murine Apaf1 by one amino acid.
    Isotyp
    IgG
    Top Product
    Discover our top product APAF1 Primärantikörper
  • Applikationshinweise
    Working dilution: Optimal dilution should be determined by the end user.
    The following are guidelines only:
    IHC(1 - 2 μg/mL) IF (10 μg/mL) WB(1 - 2 μg/mL)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    PBS, pH 7.4
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Handhabung
    Dilute in PBS or medium that is identical to that used in the assay system.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    APAF1 (Apoptotic Peptidase Activating Factor 1 (APAF1))
    Andere Bezeichnung
    Apaf1 (APAF1 Produkte)
    Synonyme
    APAF1 antikoerper, ARK antikoerper, Apaf-1 antikoerper, Apaf1 antikoerper, CG6829 antikoerper, D-Apaf-1 antikoerper, DARK antikoerper, Dapaf-1 antikoerper, Dapaf-1/HAC-1 antikoerper, Dark antikoerper, Dark/Apaf-I antikoerper, Dark/Dapaf-1/HAC1 antikoerper, Dark/Hac-1/dApaf-1 antikoerper, Dark/Hac-1/dApaf1 antikoerper, Dmel\\CG6829 antikoerper, Hac-1 antikoerper, Hac-1/Dark antikoerper, Hac1 antikoerper, T1 antikoerper, anon-53Fa antikoerper, apaf-1 antikoerper, apaf1 antikoerper, arc antikoerper, ark antikoerper, dAPAF-1 antikoerper, dApaf-1 antikoerper, dApaf-1/DARK/HAC-1 antikoerper, dApaf1 antikoerper, dArk antikoerper, dapaf antikoerper, dapaf-1 antikoerper, dapaf-1L antikoerper, dapaf-1S antikoerper, dark antikoerper, dark/dapaf-1/hac-1 antikoerper, dark/hac-1/dapaf-1 antikoerper, hac-1 antikoerper, hac1 antikoerper, l(2)SH0173 antikoerper, APAF-1 antikoerper, CED4 antikoerper, 6230400I06Rik antikoerper, Apaf1l antikoerper, fog antikoerper, mKIAA0413 antikoerper, zgc:136543 antikoerper, Death-associated APAF1-related killer antikoerper, apoptotic peptidase activating factor 1 L homeolog antikoerper, apoptotic peptidase activating factor 1 antikoerper, Dark antikoerper, apaf1.L antikoerper, apaf1 antikoerper, APAF1 antikoerper, Apaf1 antikoerper
    Hintergrund
    The mammalian homologues of the key cell death gene CED-4 in C. elegans has been identified recently from human and mouse and designated Apaf1 (for apoptosis proteaseactivating factor 1). Apaf1 binds to cytochrome c (Apaf2) and caspase-9 (Apaf3), which leads to caspase-9 activation. Activated caspase-9 in turn cleaves and activates caspase-3, one of the key proteases responsible for the proteolytic cleavage of many key proteins in apoptosis. Apaf1 can also associate with caspase-4 and caspase-8. Apaf1 is ubiquitously expressed in human tissues.

    Apoptotic protease-activating factor 1, APAF-1 Gene name: APAF1, KIAA0413, CED4
    Gen-ID
    317
    UniProt
    O14727
    Pathways
    p53 Signalweg, Apoptose, Caspase Kaskade in der Apoptose, Tube Formation, Positive Regulation of Endopeptidase Activity
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