Nibrin Antikörper (AA 467-615)
(2 Referenzen)-
- Target Alle Nibrin (NBN) Antikörper anzeigen
- Nibrin (NBN)
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Bindungsspezifität
- AA 467-615
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Reaktivität
- Human
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Wirt
- Maus
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Klonalität
- Monoklonal
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Konjugat
- Dieser Nibrin Antikörper ist unkonjugiert
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Applikation
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)
- Verwendungszweck
- NBN Antibody
- Aufreinigung
- Purified antibody
- Immunogen
- Purified recombinant fragment of human NBN (AA: 467-615) expressed in E. Coli.
- Klon
- 7E4C2
- Isotyp
- IgG2a
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anti-Nibrin (NBN) (AA 461-754) antibody
NBN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 3A2 unconjugated
anti-Nibrin (NBN) (AA 461-754) antibodyNBN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 3A9 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 8E7 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 2F5 unconjugated
anti-Nibrin (NBN) (AA 183-460) antibodyNBN Reaktivität: Human WB, IHC, IHC (p) Wirt: Maus Monoclonal 6E11 unconjugated
anti-Nibrin (NBN) (AA 435-754) antibodyNBN Reaktivität: Human WB, IHC Wirt: Kaninchen Polyclonal unconjugated
anti-Nibrin (NBN) (AA 645-754) antibodyNBN Reaktivität: Human WB, ELISA Wirt: Maus Monoclonal 3E4 unconjugated
anti-Nibrin (NBN) antibodyKO Validated NBN Reaktivität: Human WB, IF, ICC, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Nibrin (NBN) (AA 714-745), (C-Term) antibodyNBN Reaktivität: Human, Maus, Ratte WB, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
anti-Nibrin (NBN) (pSer343) antibodyNBN Reaktivität: Maus WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
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- Applikationshinweise
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ELISA: 1/10000
FCM: 1/200 - 1/400
ICC: 1/200 - 1/1000
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
- Purified antibody in PBS with 0.05 % sodium azide.
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- 4 °C,-20 °C
- Informationen zur Lagerung
- Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, (2012) (PubMed).
: "Functional NBS1 polymorphism is associated with occurrence and advanced disease status of nasopharyngeal carcinoma." in: Molecular carcinogenesis, Vol. 50, Issue 9, pp. 689-96, (2011) (PubMed).
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: "Identification of a novel NBN truncating mutation in a family with hereditary prostate cancer." in: Familial cancer, Vol. 11, Issue 4, pp. 595-600, (2012) (PubMed).
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- Target
- Nibrin (NBN)
- Andere Bezeichnung
- NBN (NBN Produkte)
- Hintergrund
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Mutations in this gene are associated with Nijmegen breakage syndrome, an autosomal recessive chromosomal instability syndrome characterized by microcephaly, growth retardation, immunodeficiency, and cancer predisposition. The encoded protein is a member of the MRE11/RAD50 double-strand break repair complex which consists of 5 proteins. This gene product is thought to be involved in DNA double-strand break repair and DNA damage-induced checkpoint activation.
- Molekulargewicht
- 85 kDa
- Gen-ID
- 4683
- UniProt
- O60934
- Pathways
- DNA Reparatur, Production of Molecular Mediator of Immune Response
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