Transferrin Receptor Antikörper (AA 608-727)

Produktnummer ABIN1724899

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Transferrin Receptor in WB und ELISA. Er zeigt eine Reaktivität gegenüber Human, Maus, Ratte und Affe und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für Transferrin Receptor Antikörper (AA 608-727) (ABIN1724899)

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Reaktivität: Human, Maus, Ratte, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Transferrin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 1A1B2

Produktdetails anti-Transferrin Receptor Antikörper

Bindungsspezifität: AA 608-727

Verwendungszweck: TFRC Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human TFRC (AA: 608-727) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-Transferrin Receptor Antikörper (ABIN1724899)

Płoszyńska, Ruckemann-Dziurdzińska, Jóźwik, Mikosik, Lisowska, Balcerska, Witkowski: "Cytometric evaluation of transferrin receptor 1 (CD71) in childhood acute lymphoblastic leukemia." in: Folia histochemica et cytobiologica / Polish Academy of Sciences, Polish Histochemical and Cytochemical Society, Vol. 50, Issue 2, pp. 304-11, (2012) (PubMed).

Jian, Yang, Huang: "Src regulates Tyr(20) phosphorylation of transferrin receptor-1 and potentiates breast cancer cell survival." in: The Journal of biological chemistry, Vol. 286, Issue 41, pp. 35708-15, (2011) (PubMed).

Details zu Transferrin Receptor

Target: Transferrin Receptor (TFRC) (Transferrin Receptor (p90, CD71) (TFRC))

Andere Bezeichnung: TFRC

Hintergrund: Transferrin receptor is a carrier protein for transferrin. It is needed for the import of iron into the cell and is regulated in response to intracellular iron concentration. Low iron concentrations promote increased levels of transferrin receptor, to increase iron intake into the cell. Thus, transferrin receptor maintains cellular iron homeostasis. Expression of human TFR1, but not human TFR2, in hamster cell lines markedly enhanced the infection of viruses pseudotyped with the glycoprotein of Machupo, Guanarito, and Junin viruses, but not with those of Lassa or lymphocytic choriomeningitis viruses. An anti-TFR1 antibody efficiently inhibited the replication of Machupo, Guanarito, Junin, and Sabia viruses, but not that of Lassa virus.TFR1 is a cellular receptor for New World hemorrhagic fever arenaviruses.

Molekulargewicht: 85 kDa

UniProt: P02786

Pathways: Transition Metal Ion Homeostasis