BMPR1A Antikörper (AA 179-378)

Produktnummer ABIN1724746

Produktdetails anti-BMPR1A Antikörper

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Bindungsspezifität: AA 179-378

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BMPR1A Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS)

Verwendungszweck: BMPR1A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human BMPR1A (AA: 179-378 ) expressed in E. Coli.

Klon: 4B7B2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-BMPR1A Antikörper (ABIN1724746)

Nickel, Kotzsch, Sebald, Mueller: "Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 67, Issue Pt 5, pp. 551-5, (2011) (PubMed).

Nieminen, Abdel-Rahman, Ristimäki, Lappalainen, Lahermo, Mecklin, Järvinen, Peltomäki: "BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency." in: Gastroenterology, Vol. 141, Issue 1, pp. e23-6, (2011) (PubMed).

Details zu BMPR1A

Target: BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Andere Bezeichnung: BMPR1A (BMPR1A Produkte)

Hintergrund:

Description: The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

Aliases: ALK3, SKR5, CD292, ACVRLK3, 10q23del

Molekulargewicht: 60kDa

Gen-ID: 657

HGNC: 657

UniProt: P36894

Pathways: Stem Cell Maintenance