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BMPR1A Antikörper (C-Term)

BMPR1A Reaktivität: Human, Maus WB, IHC (p) Wirt: Kaninchen Polyclonal RB01772 unconjugated
Produktnummer ABIN1882067
  • Target Alle BMPR1A Antikörper anzeigen
    BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))
    Bindungsspezifität
    • 25
    • 16
    • 12
    • 9
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 6
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 166-196, C-Term
    Reaktivität
    • 102
    • 52
    • 33
    • 1
    Human, Maus
    Wirt
    • 117
    • 7
    • 1
    Kaninchen
    Klonalität
    • 119
    • 6
    Polyklonal
    Konjugat
    • 44
    • 14
    • 13
    • 12
    • 11
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser BMPR1A Antikörper ist unkonjugiert
    Applikation
    • 114
    • 83
    • 48
    • 34
    • 8
    • 6
    • 4
    • 3
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
    Immunogen
    This BMPR1A antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 166-196 amino acids from the C-terminal region of human BMPR1A.
    Klon
    RB01772
    Isotyp
    Ig Fraction
    Top Product
    Discover our top product BMPR1A Primärantikörper
  • Applikationshinweise
    WB: 1:1000. WB: 1:1000. IHC-P: 1:50~100
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Haltbarkeit
    6 months
  • Kamiya, Shuxian, Yamaguchi, Phipps, Aruwajoye, Adapala, Yuan, Kim, Feng: "Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength." in: Bone, Vol. 91, pp. 53-63, (2017) (PubMed).

    Hayano, Komatsu, Pan, Mishina: "Augmented BMP signaling in the neural crest inhibits nasal cartilage morphogenesis by inducing p53-mediated apoptosis." in: Development (Cambridge, England), Vol. 142, Issue 7, pp. 1357-67, (2015) (PubMed).

    Srikanth, Kim, Das, Kessler: "BMP signaling induces astrocytic differentiation of clinically derived oligodendroglioma propagating cells." in: Molecular cancer research : MCR, Vol. 12, Issue 2, pp. 283-94, (2014) (PubMed).

    Zhang, Feng, Yang, Koga, Teitelbaum: "The bone morphogenetic protein signaling pathway is upregulated in a mouse model of total parenteral nutrition." in: The Journal of nutrition, Vol. 139, Issue 7, pp. 1315-21, (2009) (PubMed).

    Pache, Schäfer, Wiesemann, Springer, Liebau, Reinhardt, August, Pavenstädt, Bek: "Upregulation of Id-1 via BMP-2 receptors induces reactive oxygen species in podocytes." in: American journal of physiology. Renal physiology, Vol. 291, Issue 3, pp. F654-62, (2006) (PubMed).

    Waite, Eng: "BMP2 exposure results in decreased PTEN protein degradation and increased PTEN levels." in: Human molecular genetics, Vol. 12, Issue 6, pp. 679-84, (2003) (PubMed).

    Zhou, Woodford-Richens, Lehtonen, Kurose, Aldred, Hampel, Launonen, Virta, Pilarski, Salovaara, Bodmer, Conrad, Dunlop, Hodgson, Iwama, Järvinen, Kellokumpu, Kim, Leggett, Markie, Mecklin, Neale et al.: "Germline mutations in BMPR1A/ALK3 cause a subset of cases of juvenile polyposis syndrome and of Cowden and Bannayan-Riley-Ruvalcaba syndromes. ..." in: American journal of human genetics, Vol. 69, Issue 4, pp. 704-11, (2001) (PubMed).

    Aström, Jin, Imamura, Röijer, Rosenzweig, Miyazono, ten Dijke, Stenman: "Chromosomal localization of three human genes encoding bone morphogenetic protein receptors." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 10, Issue 3, pp. 299-302, (1999) (PubMed).

    ten Dijke, Ichijo, Franzén, Schulz, Saras, Toyoshima, Heldin, Miyazono: "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity." in: Oncogene, Vol. 8, Issue 10, pp. 2879-87, (1993) (PubMed).

  • Target
    BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))
    Andere Bezeichnung
    BMPR1A (BMPR1A Produkte)
    Synonyme
    10q23del antikoerper, ACVRLK3 antikoerper, ALK3 antikoerper, CD292 antikoerper, SKR5 antikoerper, 1110037I22Rik antikoerper, AU045487 antikoerper, BMPR-IA antikoerper, Bmpr antikoerper, BMPR-1 antikoerper, BRK-1 antikoerper, BMPR1A antikoerper, acvrlk3 antikoerper, alk-3 antikoerper, alk3 antikoerper, cd292 antikoerper, skr5 antikoerper, BR1a antikoerper, alk3tr antikoerper, bmpr1a antikoerper, zgc:136731 antikoerper, wu:fe05b06 antikoerper, wu:fe06e10 antikoerper, zgc:92227 antikoerper, bone morphogenetic protein receptor type 1A antikoerper, bone morphogenetic protein receptor, type 1A antikoerper, bone morphogenetic protein receptor type 1A S homeolog antikoerper, bone morphogenetic protein receptor, type IAa antikoerper, bone morphogenetic protein receptor, type IAb antikoerper, BMPR1A antikoerper, Bmpr1a antikoerper, bmpr1a antikoerper, bmpr1a.S antikoerper, bmpr1aa antikoerper, bmpr1ab antikoerper
    Hintergrund
    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.
    Molekulargewicht
    60198
    NCBI Accession
    NP_004320
    UniProt
    P36894
    Pathways
    Stem Cell Maintenance
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