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BMPR1A Antikörper (AA 179-378)

Dieses Anti-BMPR1A-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von BMPR1A in WB, ELISA, IHC, FACS und ICC. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.
Produktnummer ABIN1724745

Kurzübersicht für BMPR1A Antikörper (AA 179-378) (ABIN1724745)

Target

Alle BMPR1A Antikörper anzeigen
BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

Reaktivität

  • 76
  • 54
  • 36
  • 2
  • 1
Human, Maus

Wirt

  • 96
  • 10
  • 1
Maus

Klonalität

  • 98
  • 9
Monoklonal

Konjugat

  • 57
  • 8
  • 7
  • 6
  • 5
  • 4
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser BMPR1A Antikörper ist unkonjugiert

Applikation

  • 95
  • 55
  • 46
  • 26
  • 14
  • 11
  • 8
  • 6
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon

4B7B2
  • Bindungsspezifität

    • 16
    • 10
    • 9
    • 8
    • 8
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 179-378

    Verwendungszweck

    BMPR1A Antibody

    Aufreinigung

    Ascitic fluid

    Immunogen

    Purified recombinant fragment of human BMPR1A (AA: 179-378 ) expressed in E. Coli.

    Isotyp

    IgG1
  • Applikationshinweise

    ELISA: 1/10000

    FCM: 1/200 - 1/400

    ICC: 1/200 - 1/1000

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Buffer

    Ascitic fluid containing 0.03 % sodium azide.

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
  • Nickel, Kotzsch, Sebald, Mueller: "Purification, crystallization and preliminary data analysis of the ligand-receptor complex of the growth and differentiation factor 5 variant R57A (GDF5R57A) and BMP receptor IA (BRIA)." in: Acta crystallographica. Section F, Structural biology and crystallization communications, Vol. 67, Issue Pt 5, pp. 551-5, (2011) (PubMed).

    Nieminen, Abdel-Rahman, Ristimäki, Lappalainen, Lahermo, Mecklin, Järvinen, Peltomäki: "BMPR1A mutations in hereditary nonpolyposis colorectal cancer without mismatch repair deficiency." in: Gastroenterology, Vol. 141, Issue 1, pp. e23-6, (2011) (PubMed).

  • Target

    BMPR1A (Bone Morphogenetic Protein Receptor 1A (BMPR1A))

    Andere Bezeichnung

    BMPR1A

    Hintergrund

    The bone morphogenetic protein (BMP) receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A and BMPR1B and the type II receptor BMPR2. These receptors are also closely related to the activin receptors, ACVR1 and ACVR2. The ligands of these receptors are members of the TGF-beta superfamily. TGF-betas and activins transduce their signals through the formation of heteromeric complexes with 2 different types of serine (threonine) kinase receptors: type I receptors of about 50-55 kD and type II receptors of about 70-80 kD. Type II receptors bind ligands in the absence of type I receptors, but they require their respective type I receptors for signaling, whereas type I receptors require their respective type II receptors for ligand binding.

    Molekulargewicht

    60 kDa

    Gen-ID

    657

    UniProt

    P36894

    Pathways

    Stem Cell Maintenance
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