GM-CSF Antikörper (AA 18-144)

Produktnummer ABIN1724740

Dieses Maus Monoklonal-Antikörper erkennt spezifisch GM-CSF in ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für GM-CSF Antikörper (AA 18-144) (ABIN1724740)

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser GM-CSF Antikörper ist unkonjugiert

Applikation: ELISA

Klon: 3D3

Produktdetails anti-GM-CSF Antikörper

Bindungsspezifität: AA 18-144

Verwendungszweck: CSF2 Antibody

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human CSF2 (aa18-144) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: ELISA: 1/10000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Ascitic fluid containing 0.03 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-GM-CSF Antikörper (ABIN1724740)

He, Shumansky, Connett, Anthonisen, Paré, Sandford: "Association of genetic variations in the CSF2 and CSF3 genes with lung function in smoking-induced COPD." in: The European respiratory journal, Vol. 32, Issue 1, pp. 25-34, (2008) (PubMed).

Fuxman Bass, Alvarez, Gabelloni, Vermeulen, Amaral, Geffner, Trevani: "GM-CSF enhances a CpG-independent pathway of neutrophil activation triggered by bacterial DNA." in: Molecular immunology, Vol. 46, Issue 1, pp. 37-44, (2008) (PubMed).

Hansen, Hercus, McClure, Stomski, Dottore, Powell, Ramshaw, Woodcock, Xu, Guthridge, McKinstry, Lopez, Parker: "The structure of the GM-CSF receptor complex reveals a distinct mode of cytokine receptor activation." in: Cell, Vol. 134, Issue 3, pp. 496-507, (2008) (PubMed).

Details zu GM-CSF

Target: GM-CSF (CSF2) (Colony Stimulating Factor 2 (Granulocyte-Macrophage) (CSF2))

Andere Bezeichnung: CSF2

Hintergrund: The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes and macrophages. The active form of the protein is found extracellularly as a homodimer. This gene has been localized to a cluster of related genes at chromosome region 5q31, which is known to be associated with interstitial deletions in the 5q- syndrome and acute myelogenous leukemia. Other genes in the cluster include those encoding interleukins 4, 5, and 13.

Molekulargewicht: 16 kDa

Gen-ID: 1437

UniProt: P04141

Pathways: JAK-STAT Signalweg, Cellular Response to Molecule of Bacterial Origin