MLLT1 Antikörper (AA 414-472)

Produktnummer ABIN1721516

Der Maus Monoklonal anti-MLLT1 Antikörper wird verwendet zum Nachweis von MLLT1 in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für MLLT1 Antikörper (AA 414-472) (ABIN1721516)

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLLT1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 3-1-1

Produktdetails anti-MLLT1 Antikörper

Bindungsspezifität: AA 414-472

Spezifität: Reacts with human ENL.

Aufreinigung: Purified (protein G)

Immunogen: Maltose-binding fusion protein containing ENL amino acids 414-472 (Accession no. NP_005925).

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Working dilution: Optimal dilution should be determined by the end user.
The following are guidelines only :
WB(1 - 5 μg/mL)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.4.

Handhabung: Dilute in PBS or medium that is identical to that used in the assay system.

Lagerung: -20 °C

Informationen zur Lagerung: Stable for at least one year at -20°C. Avoid multiple freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu MLLT1

Target: MLLT1 (MLLT1, super elongation complex subunit (MLLT1))

Andere Bezeichnung: ENL

Hintergrund: The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.

Protein ENL YEATS domain-containing protein 1 LTG19 YEATS1 Gene name : MLLT1

Gen-ID: 4298

UniProt: Q03111