MGC84026 antikoerper, MLLT1 antikoerper, ENL antikoerper, LTG19 antikoerper, YEATS1 antikoerper, AA407901 antikoerper, BAM11 antikoerper, MLLT1, super elongation complex subunit antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 L homeolog antikoerper, myeloid/lymphoid or mixed-lineage leukemia; translocated to, 1 antikoerper, Mllt1 antikoerper, MLLT1 antikoerper, mllt1.L antikoerper, mllt1 antikoerper
Hintergrund
The AF4 and ENL (Eleven nineteen Leukemia) protein families are the most frequent MLL fusion partners accounting for two-thirds of MLL-associated leukemia incidence. The ENL family includes ENL and AF9 and has structural homology to the yeast Anc1 protein. ENL is a nuclear protein that is capable of activating transcription from synthetic reporter genes in both lymphoid and myeloid cells as well as in yeast. Deletion muta-genesis demonstrated that the minimal portion of ENL required for activation of transcription was localized to its C-terminal 90 amino acids. This region is highly conserved between ENL and AF9 and is retained in all Hrx-ENL and Hrx-AF9 fusion proteins. Thus, the leukemogenic contribution and transcriptional activation potential of ENL colocalize to its highly conserved carboxy terminus.
Protein ENL YEATS domain-containing protein 1 LTG19 YEATS1 Gene name : MLLT1