EPOR Antikörper

Produktnummer ABIN1720915

Dieses Maus Monoklonal-Antikörper erkennt spezifisch EPOR in FACS und cELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für EPOR Antikörper (ABIN1720915)

Target: EPOR (Erythropoietin Receptor (EPOR))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser EPOR Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Cell-ELISA (cELISA)

Klon: VP-2E8

Produktdetails anti-EPOR Antikörper

Spezifität: Anti-human Epo-R

Produktmerkmale: Selection: Based on recognition of the complete native protein expressed on transfected mammalian cells

Aufreinigung: Protein G

Immunogen: genetic immunisation with cDNA encoding the ECD of human Epo-R

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration.

Kommentare:

Synonyms: Erythropoietin receptor

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS, pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C

Informationen zur Lagerung: short term: 2 °C - 8 °C, long term: -20 °C

Referenzen für anti-EPOR Antikörper (ABIN1720915)

Maxwell, Melendez-Rodríguez, Matchett, Aragones, Ben-Califa, Jaekel, Hengst, Lindner, Bernardini, Brockmeier, Fandrey, Grunert, Oster, Mittelman, El-Tanani, Thiersch, Schneider Gasser, Gassmann et al.: "Novel antibodies directed against the human erythropoietin receptor: creating a basis for clinical implementation. ..." in: British journal of haematology, Vol. 168, Issue 3, pp. 429-42, (2015) (PubMed).

Hedley, Allan, Xenocostas: "The role of erythropoietin and erythropoiesis-stimulating agents in tumor progression." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 20, pp. 6373-80, (2011) (PubMed).

Details zu EPOR

Target: EPOR (Erythropoietin Receptor (EPOR))

Andere Bezeichnung: EPOR

Hintergrund: Erythropoietin receptor (Epo-R) belongs to the cytokine receptor family and is a 507 amino acid type I transmembrane protein. EpoR pre-exists as dimers which changes the homodimerized state after binding of its 34 kDa ligand erythropoietin (Epo). Erythropoietin is the primary regulator of erythropoiesis, and promotes the survival, proliferation, and differentiation of erythroid progenitor cells. Both, Epo and Epo-R are essential for the production of red blood cells due to Epo exerts its function through the Epo receptor. The Epo-R is also expressed in many organs outside the bone marrow, suggesting that Epo is a pleiotropic anti-apoptotic factor. Signaling pathways have been shown to influence numerous cellular functions in normal and tumor cells, including proliferation, apoptosis, and drug resistance.

UniProt: P19235

Pathways: JAK-STAT Signalweg