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GCAP1 Antikörper (AA 51-150)

Der Kaninchen Polyklonal Anti-GCAP1-Antikörper wurde für ELISA, WB, IF (cc), IF (p), IHC (p), IHC (fro) und ICC validiert. Er ist geeignet, GCAP1 in Proben von Maus und Ratte zu detektieren.
Produktnummer ABIN1714544

Kurzübersicht für GCAP1 Antikörper (AA 51-150) (ABIN1714544)

Target

Alle GCAP1 (GUCA1A) Antikörper anzeigen
GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

Reaktivität

  • 21
  • 17
  • 16
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Maus, Ratte

Wirt

  • 34
  • 1
Kaninchen

Klonalität

  • 34
  • 1
Polyklonal

Konjugat

  • 12
  • 4
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GCAP1 Antikörper ist unkonjugiert

Applikation

  • 29
  • 16
  • 12
  • 12
  • 10
  • 5
  • 2
  • 1
  • 1
ELISA, Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 14
    • 9
    • 5
    • 4
    • 1
    • 1
    • 1
    AA 51-150

    Kreuzreaktivität

    Maus, Ratte

    Homologie

    Human,Dog,Cow,Sheep,Horse

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GCAP1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    GCAP1 (GUCA1A) (Guanylate Cyclase Activator 1A (Retina) (GUCA1A))

    Andere Bezeichnung

    GCAP1

    Hintergrund

    Synonyms: COD3, GCAP 1, GCAP, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activating Protein Photoreceptor 1, Guanylate Cyclase Activator 1A, Guanylate Cyclase Activator 1A, Guanylin 1, Guanylin 1, guanylyl cyclase activating protein 1, Guanylyl cyclase-activating protein 1, GUC1A_HUMAN, GUCA, GUCA1, GUCA1A, GUCA1A.

    Background: intracellular stimulation of guanylate cyclase (GC) by calcium, a key event in the recovery of the dark state of rod photoreceptors after exposure to light, is mediated by guanylate cyclase-activating protein (GCAP1). GCAPs are calcium-The binding proteins belonging to the calmodulin superfamily. GCAP1 is a calcium-binding protein that stimulates synthesis of c-GMP in photoreceptors. GCAP1 is present in rod and cone photoreceptor outer segments where phototransduction occurs. In contrast to other calcium-binding proteins from the calmodulin superfamily, the calcium-free form of GCAP1 stimulates the effector enzyme. By molecular cloning of human and mouse GCAP cDNA, the known mammalian GCAPs are found to be more than 90 % similar, consisting of 201 to 205 amino acids, and containing three identically conserved calcium-binding sites. A related protein, GCAP2, is detectable only in the retina and results from a gene duplication event.

    Gen-ID

    2978

    Pathways

    Regulation of G-Protein Coupled Receptor Protein Signaling, Phototransduction
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