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HIC1 Antikörper (AA 501-650)

This anti-HIC1 antibody (ABIN1714195) is a Rabbit Polyclonal antibody detecting HIC1 in WB, ELISA, IF (cc), IF (p), IHC (fro), IHC (p), ICC. Suitable for Mouse.
Produktnummer ABIN1714195

Kurzübersicht für HIC1 Antikörper (AA 501-650) (ABIN1714195)

Target

Alle HIC1 Antikörper anzeigen
HIC1 (Hypermethylated in Cancer 1 (HIC1))

Reaktivität

  • 27
  • 19
  • 5
  • 4
  • 4
  • 4
  • 3
  • 2
  • 2
  • 2
  • 1
Maus

Wirt

  • 38
  • 4
  • 1
Kaninchen

Klonalität

  • 39
  • 4
Polyklonal

Konjugat

  • 20
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser HIC1 Antikörper ist unkonjugiert

Applikation

  • 37
  • 19
  • 12
  • 12
  • 3
  • 3
  • 2
  • 2
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)
  • Bindungsspezifität

    • 14
    • 9
    • 5
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 501-650

    Kreuzreaktivität

    Maus

    Homologie

    Human,Rat,Dog,Cow,Pig,Horse,Chicken

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human HIC1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Li, Yao, Wu, Zhang, Wang, Chen, Fu, Weng, Wang: "Loss of hypermethylated in cancer 1 (HIC1) promotes lung cancer progression." in: Cellular signalling, Vol. 53, pp. 162-169, (2019) (PubMed).

  • Target

    HIC1 (Hypermethylated in Cancer 1 (HIC1))

    Andere Bezeichnung

    HIC1

    Hintergrund

    Synonyms: Hic 1, Hic-1, Hic1, HIC1_HUMAN, Hypermethylated in cancer 1, Hypermethylated in cancer 1 protein, ZBTB29, Zinc finger and BTB domain-containing protein 29, ZNF901.

    Background: Hypermethylated in cancer (HIC-1) was originally identified as a target of p53-induced gene expression. HIC-1 is deleted in the genetic disorder Miller-Dieker syndrome (MDS), and the expression of HIC-1 is also frequently suppressed in leukemia and various cancers due to the hypermethylation of specific DNA regions and the resulting transcriptional silencing. These and other studies indicate that HIC-1 acts as a putative tumor suppressor protein that mediates transcriptional repression. HIC-1 is ubiquitously expressed in adult tissues and its structure is defined by five zinc fingers and an N-terminal broad complex POZ (or BTB) domain. In several BTB/POZ containing proteins, including BCL-6 and the promyelocytic leukemia zinc-finger (PLZF) oncoprotein, this domain interacts with the SMRT/N-CoR-mSin3A HDAC complex and is directly involved in repressing and silencing gene transcription. When this domain is deleted, as with the oncogenic PLZF-RAR chimera of promyelocytic leukemias, this transcriptional repression is attenuated. Conversely, HIC-1 does not interact with components of the HDAC complex, suggesting that HIC-1-induced transcriptional repression is unassociated with the POZ/BTB domain.

    Gen-ID

    3090

    Pathways

    Positive Regulation of Response to DNA Damage Stimulus
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