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DNMT3L Antikörper (AA 131-230)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch DNMT3L in WB, ELISA, IF (cc), IF (p), ICC, IHC (p) und IHC (fro). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1713766

Kurzübersicht für DNMT3L Antikörper (AA 131-230) (ABIN1713766)

Target

Alle DNMT3L (TRDMT1) Antikörper anzeigen
DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

Reaktivität

  • 73
  • 19
  • 4
Human

Wirt

  • 69
  • 12
Kaninchen

Klonalität

  • 71
  • 10
Polyklonal

Konjugat

  • 38
  • 6
  • 5
  • 5
  • 3
  • 3
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser DNMT3L Antikörper ist unkonjugiert

Applikation

  • 65
  • 35
  • 17
  • 12
  • 12
  • 7
  • 6
  • 6
  • 5
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
  • Bindungsspezifität

    • 14
    • 8
    • 7
    • 7
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 131-230

    Kreuzreaktivität

    Human

    Homologie

    Mouse,Rat

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human Dnmt3L

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    ICC 1:100-500

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    DNMT3L (TRDMT1) (DNA (Cytosine-5-)-Methyltransferase 3 Like (TRDMT1))

    Andere Bezeichnung

    Dnmt3L

    Hintergrund

    Synonyms: Cytosine 5 methyltransferase 3 like protein, DNA cytosine 5 methyltransferase 3 like, DNA cytosine-5-methyltransferase 3-like, DNA Cytosine 5 Methyltransferase 3 Like Protein, DNA Methyltransferase 3 Like Protein, DNM3L_HUMAN, Dnmt 3L, Dnmt3l, Human cytosine 5 methyltransferase 3 like protein, MGC1090.

    Background: Methylation at the 5'-position of cytosine is the only known naturally occurring covalent modification of the mammalian genome. DNA methylation requires the enzymatic activity of DNA 5-cytosine methyltransferase (Dnmt) proteins, which catalyze the transfer of a methyl group from S-adenosyl methionine to the 5'-position of cytosines, thereby repressing expression of the target gene. Dnmt3L (DNA (cytosine-5)-methyltransferase 3-like) is a 387 amino acid protein that contains one ADD-type zinc finger and is a member of the Dnmt family. Localized to the nucleus and expressed at lows levels in thymus, testis and ovary, Dnmt3L does not exhibit DNA methyltransferase activity, but is able to stimulate de novo methylation by Dnmt3 and is thought to play a key role in the establishment of genomic imprints. Additionally, Dnmt3L interacts with histone deacetylase 1 (HDAC1) and, through this interaction, mediates transcriptional repression. Multiple isoforms of Dnmt3L exist due to alternative splicing events.

    Gen-ID

    29947
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