CEP57 Antikörper (AA 51-150)

Produktnummer ABIN1713745

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch CEP57 in IF (cc), IF (p), IHC (p) und IHC (fro). Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für CEP57 Antikörper (AA 51-150) (ABIN1713745)

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CEP57 Antikörper ist unkonjugiert

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-CEP57 Antikörper

Bindungsspezifität: AA 51-150

Verwendungszweck: CEP57 Polyclonal Antibody

Homologie: Human,Mouse,Rat,Dog,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CEP57

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu CEP57

Target: CEP57 (Centrosomal Protein 57kDa (CEP57))

Andere Bezeichnung: CEP57

Hintergrund:

Synonyms: Centrosomal protein 57 kDa, Centrosomal protein of 57 kDa, Cep57, Cep57 protein, CEP57_HUMAN, FGF2 interacting protein, FGF2-interacting protein, KIAA0092, MVA2, PIG8, proliferation inducing protein 8, Testis specic protein 57, Testis-specic protein 57, Translokin, TSP57.

Background: CEP57 (centrosomal protein 57 kDa), also known as PIG8, TSP57 or Translokin, is a 500 amino acid protein that localizes to both the nucleus and the cytoplasm, specifically associating with microtubules at the centrosome. Expressed ubiquitously, CEP57 exists as a homodimer that functions to mediate the mitogenic activity and nuclear translocation of FGF-2, an internalized growth factor, thereby regulating FGF-2 signaling pathways. Additionally, CEP57 is thought to play a role in spermatogenesis, possibly via the indirect regulation of gene expression. Human CEP57 shares 88 % sequence identity with its mouse and bovine orthologs, suggesting a highly conserved role between species. Multiple isoforms of CEP57 exist due to alternative splicing events.

Pathways: M Phase, Maintenance of Protein Location, Protein targeting to Nucleus, Growth Factor Binding