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GPBAR1 Antikörper

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch GPBAR1 in WB, IF (p) und IHC (p). Er zeigt eine Reaktivität gegenüber Human.
Produktnummer ABIN1713517

Kurzübersicht für GPBAR1 Antikörper (ABIN1713517)

Target

Alle GPBAR1 Antikörper anzeigen
GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

Reaktivität

  • 50
  • 13
  • 13
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Human

Wirt

  • 50
  • 2
Kaninchen

Klonalität

  • 50
  • 2
Polyklonal

Konjugat

  • 17
  • 4
  • 4
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GPBAR1 Antikörper ist unkonjugiert

Applikation

  • 27
  • 12
  • 9
  • 4
  • 3
  • 3
  • 2
Western Blotting (WB), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
  • Kreuzreaktivität

    Human

    Aufreinigung

    Purified by Protein A.

    Immunogen

    KLH conjugated synthetic peptide derived from human GPBAR1

    Isotyp

    IgG
  • Applikationshinweise

    WB 1:300-5000
    IHC-P 1:200-400
    IF(IHC-P) 1:50-200

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1 μg/μL

    Buffer

    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

    Konservierungsmittel

    ProClin

    Vorsichtsmaßnahmen

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    Haltbarkeit

    12 months
  • Target

    GPBAR1 (G Protein-Coupled Bile Acid Receptor 1 (GPBAR1))

    Andere Bezeichnung

    GPBAR1

    Hintergrund

    Synonyms: BG 37, BG37, G protein coupled bile acid receptor 1, G protein coupled bile acid receptor BG 37, G protein coupled bile acid receptor BG37, G-protein coupled bile acid receptor 1, G-protein coupled receptor GPCR19, GPBAR 1, GPBAR_HUMAN, GPBAR1, GPCR 19, GPCR, GPCR19, GPR 131, GPR131, hBG 37, hBG37, hGPCR 19, hGPCR19, M BAR, M-BAR, Membrane bile acid receptor, Membrane type receptor for bile acids, Membrane-type receptor for bile acids, MGC40597, TGR 5, TGR5.

    Background: The G protein-coupled receptor TGR5 is a 330-amino acid protein that is almost universally expressed in human tissues including heart, skeletal muscle, spleen, kidney, liver, small intestine, placenta, and leukocytes, but not in brain, colon (without mucosa), thymus, or lung. TGR5 is sensitive to bile acids and responds through a significant mechanism that coordinates energy homeostasis. Bile acids activate mitogen-activated protein (MAP) kinase pathways, specifically induce TGR5 internalization, promote an increase of guanosine 5'-O-3-thio-triphosphate binding in membrane fractions, and cause rapid intracellular cAMP production. Bile acids also provoke TGR5 to suppress macrophage functions. TGR5-controlled signaling pathways may be good candidates for drug targets to treat common metabolic diseases, such as obesity, type II diabetes, hyperlipidemia, and atherosclerosis.

    Gen-ID

    151306

    Pathways

    WNT Signalweg, Hormone Transport, Sensory Perception of Sound
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